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  1. Research article

    Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity

    Pain catastrophizing (PC) is associated with more severe and disabling migraine attacks. However, factors that moderate this relationship are unknown. Failure of inhibitory control (IC), or the ability to supp...

    Rachel Galioto, Kevin C. O’Leary, J. Graham Thomas, Kathryn Demos, Richard B. Lipton, John Gunstad, Jelena M. Pavlović, Julie Roth, Lucille Rathier and Dale S. Bond

    The Journal of Headache and Pain 2017 18:41

    Published on: 29 March 2017

  2. Research article

    Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)

    Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater ...

    M. Lukács, K. Warfvinge, J. Tajti, F. Fülöp, J. Toldi, L. Vécsei and L. Edvinsson

    The Journal of Headache and Pain 2017 18:39

    Published on: 23 March 2017

  3. Review article

    Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

    Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy...

    Giorgio Sandrini, Roberto De Icco, Cristina Tassorelli, Nicola Smania and Stefano Tamburin

    The Journal of Headache and Pain 2017 18:38

    Published on: 21 March 2017

  4. Research article

    Anxiety and depression symptoms and migraine: a symptom-based approach research

    Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited inform...

    Mario Fernando Prieto Peres, Juliane P. P. Mercante, Patricia R. Tobo, Helder Kamei and Marcelo Eduardo Bigal

    The Journal of Headache and Pain 2017 18:37

    Published on: 21 March 2017

  5. Research article

    Association of excessive daytime sleepiness with migraine and headache frequency in the general population

    Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general popul...

    Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner and Michael Bjørn Russell

    The Journal of Headache and Pain 2017 18:35

    Published on: 20 March 2017

  6. Research article

    Calcitonin gene-related peptide and pain: a systematic review

    Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in mi...

    Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J. Goadsby and Messoud Ashina

    The Journal of Headache and Pain 2017 18:34

    Published on: 16 March 2017

  7. Review article

    Family studies to find rare high risk variants in migraine

    Migraine has long been known as a common complex disease caused by genetic and environmental factors. The pathophysiology and the specific genetic susceptibility are poorly understood. Common variants only exp...

    Rikke Dyhr Hansen, Anne Francke Christensen and Jes Olesen

    The Journal of Headache and Pain 2017 18:32

    Published on: 2 March 2017

  8. Research article

    A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine

    DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows su...

    Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L.H. Spierings, Roger K. Cady and Alan M. Rapoport

    The Journal of Headache and Pain 2017 18:31

    Published on: 1 March 2017

  9. Research article

    Increased levels of intramuscular cytokines in patients with jaw muscle pain

    The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with t...

    S. Louca Jounger, N. Christidis, P. Svensson, T. List and M. Ernberg

    The Journal of Headache and Pain 2017 18:30

    Published on: 27 February 2017

  10. Research article

    Primary headache disorders in the adult general population of Pakistan – a cross sectional nationwide prevalence survey

    The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakist...

    A. A. Herekar, A. Ahmad, U. L. Uqaili, B. Ahmed, J. Effendi, S. Z. Alvi, M. A. Shahab, U. Javed, A. D. Herekar, Rafiq Khanani and T. J. Steiner

    The Journal of Headache and Pain 2017 18:28

    Published on: 23 February 2017

  11. Research article

    Depression and anxiety behaviour in a rat model of chronic migraine

    Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals.

    Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong and Shengyuan Yu

    The Journal of Headache and Pain 2017 18:27

    Published on: 21 February 2017

  12. Research article

    Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI

    Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the...

    Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma and Shengyuan Yu

    The Journal of Headache and Pain 2017 18:25

    Published on: 20 February 2017

  13. Research article

    OnabotulinumtoxinA effectiveness on chronic migraine, negative emotional states and sleep quality: a single-center prospective cohort study

    OnabotulinumtoxinA (OnabotA) is considered effective in in patients with chronic migraine (CM) who failed on traditional therapies. This study was designed to evaluate the effect of OnabotA injection series on...

    Elif Ilgaz Aydinlar, Pinar Yalinay Dikmen, Seda Kosak and Ayse Sagduyu Kocaman

    The Journal of Headache and Pain 2017 18:23

    Published on: 17 February 2017

  14. Short report

    Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study

    In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus stan...

    Charly Gaul, Delphine Magis, Eric Liebler and Andreas Straube

    The Journal of Headache and Pain 2017 18:22

    Published on: 14 February 2017

  15. Review article

    Genetic and biochemical changes of the serotonergic system in migraine pathobiology

    Migraine is a brain disorder characterized by a piercing headache which affects one side of the head, located mainly at the temples and in the area around the eye. Migraine imparts substantial suffering to the...

    Claudia Francesca Gasparini, Robert Anthony Smith and Lyn Robyn Griffiths

    The Journal of Headache and Pain 2017 18:20

    Published on: 13 February 2017

  16. Research article

    Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study

    In the emergency setting, non-traumatic headache is a benign symptom in 80% of cases, but serious underlying conditions need to be ruled out.

    Claudine Angela Blum, Bettina Winzeler, Nicole Nigro, Philipp Schuetz, Silke Biethahn, Timo Kahles, Cornelia Mueller, Katharina Timper, Katharina Haaf, Janina Tepperberg, Margareth Amort, Andreas Huber, Roland Bingisser, Peter Stephan Sándor, Krassen Nedeltchev, Beat Müller…

    The Journal of Headache and Pain 2017 18:21

    Published on: 13 February 2017

  17. Research article

    The association of headache frequency with pain interference and the burden of disease is mediated by depression and sleep quality, but not anxiety, in chronic tension type headache

    A better understanding of potential relationship between mood disorders, sleep quality, pain, and headache frequency may assist clinicians in determining optimal therapeutic programs. The aim of the current st...

    María Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Ángel Guerrero-Peral, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

    The Journal of Headache and Pain 2017 18:19

    Published on: 10 February 2017

  18. Short report

    Psychiatric comorbidities and photophobia in patients with migraine

    Based on recent findings and our own impressions we took a closer look at the relationship between (inter)ictal photophobia and psychometric variables in migraine patients with photophobia.

    Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan and Christian Wöber

    The Journal of Headache and Pain 2017 18:18

    Published on: 9 February 2017

    The Erratum to this article has been published in The Journal of Headache and Pain 2017 18:33

  19. Research article

    Randomized, double-blind, crossover study comparing DFN-11 injection (3 mg subcutaneous sumatriptan) with 6 mg subcutaneous sumatriptan for the treatment of rapidly-escalating attacks of episodic migraine

    A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy.

    Roger K. Cady, Sagar Munjal, Ryan J. Cady, Heather R. Manley and Elimor Brand-Schieber

    The Journal of Headache and Pain 2017 18:17

    Published on: 7 February 2017

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