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  1. Research article

    The burden of headache disorders in Ethiopia: national estimates from a population-based door-to-door survey

    Headache disorders are the third-highest cause of disability worldwide, with migraine and medication-overuse headache (MOH) the major contributors. In Ethiopia we have shown these disorders to be highly preval...

    Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K Worku, Hallie Thomas and Timothy J Steiner

    The Journal of Headache and Pain 2017 18:58

    Published on: 25 May 2017

  2. Research article

    Treatment of withdrawal headache in patients with medication overuse headache: a pilot study

    Drug withdrawal still remains the key element in the treatment of Medication Overuse Headache (MOH), but there is no consensus about the withdrawal procedure. Still debated is the role of the steroid therapy. ...

    Sabina Cevoli, Giulia Giannini, Valentina Favoni, Rossana Terlizzi, Elisa Sancisi, Marianna Nicodemo, Stefano Zanigni, Maria Letizia Bacchi Reggiani, Giulia Pierangeli and Pietro Cortelli

    The Journal of Headache and Pain 2017 18:56

    Published on: 12 May 2017

  3. Research article

    Quality indicators in headache care: an implementation study in six Italian specialist-care centres

    Headache disorders are highly prevalent, and have a substantial and negative impact on health worldwide. They are largely treatable, but differences in structure, objectives, organization and delivery affect t...

    L. Pellesi, S. Benemei, V. Favoni, C. Lupi, E. Mampreso, A. Negro, M. Paolucci, T. J. Steiner, M. Ulivi, S. Cevoli and S. Guerzoni

    The Journal of Headache and Pain 2017 18:55

    Published on: 5 May 2017

  4. Research article

    Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

    Isometheptene is a sympathomimetic drug effective in acute migraine treatment. It is composed of two enantiomers with diverse pharmacological properties. This study investigated in pithed rats the cardiovascul...

    Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Oswaldo Hernández-Abreu, Bruce L. Daugherty, Antoinette MaassenVanDenBrink and Carlos M. Villalón

    The Journal of Headache and Pain 2017 18:52

    Published on: 4 May 2017

  5. Research article

    Prevalence and burden of headache disorders in Lithuania and their public-health and policy implications: a population-based study within the Eurolight Project

    The Eurolight project assessed the impact of headache disorders in ten EU countries, using the same structured questionnaire but varying sampling methods. In Lithuania, sample selection employed methods in lin...

    Daiva Rastenytė, Dalia Mickevičienė, Lars Jacob Stovner, Hallie Thomas, Colette Andrée and Timothy J Steiner

    The Journal of Headache and Pain 2017 18:53

    Published on: 4 May 2017

  6. Research article

    The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain

    Hyperbaric oxygen (HBO) has the potential to relieve neuropathic pain. The purpose of this study was to determine whether the NO-cGMP-PKG signaling pathway is involved in the analgesic effects of early hyperba...

    Yuanyuan Ding, Peng Yao, Tao Hong, Zhenkai Han, Baisong Zhao and Weimin Chen

    The Journal of Headache and Pain 2017 18:51

    Published on: 3 May 2017

  7. Research article

    Insufficient sleep is prevalent among migraineurs: a population-based study

    Sleep disorder and sleep complaints are common in subjects with migraine. Although the association between sleep disorders and migraine has been reported, the association between perceived insufficient sleep a...

    Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

    The Journal of Headache and Pain 2017 18:50

    Published on: 28 April 2017

  8. Research article

    The course of headache in patients with moderate-to-severe headache due to mild traumatic brain injury: a retrospective cross-sectional study

    Little is known about the long-term course of headache in patients with moderate-to-severe headache due to traumatic brain injury (TBI). We evaluated the course of headache in patients with moderate-to-severe...

    Chang-Ki Hong, Jin-Yang Joo, Yu Shik Shim, Sook Young Sim, Min A Kwon, Yong Bae Kim and Joonho Chung

    The Journal of Headache and Pain 2017 18:48

    Published on: 20 April 2017

  9. Research article

    Restless legs syndrome and tension-type headache: a population-based study

    Recent studies have shown a significant association between restless legs syndrome (RLS) and primary headache disorders. Nevertheless, information regarding the association between tension-type headache (TTH) ...

    Pil-Wook Chung, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

    The Journal of Headache and Pain 2017 18:47

    Published on: 19 April 2017

  10. Research article

    Level of physical activity, well-being, stress and self-rated health in persons with migraine and co-existing tension-type headache and neck pain

    The prevalence of migraine with co-existing tension-type headache and neck pain is high in the general population. However, there is very little literature on the characteristics of these combined conditions. ...

    Lotte Skytte Krøll, Catharina Sjödahl Hammarlund, Maria Lurenda Westergaard, Trine Nielsen, Louise Bönsdorff Sloth, Rigmor Højland Jensen and Gunvor Gard

    The Journal of Headache and Pain 2017 18:46

    Published on: 18 April 2017

  11. Research article

    Identification of subgroups of patients with tension type headache with higher widespread pressure pain hyperalgesia

    Identification of subgroups of patients with different levels of sensitization and clinical features can help to identify groups at risk and the development of better therapeutic strategies. The aim of this st...

    César Fernández-de-las-Peñas, Elena Benito-González, María Palacios-Ceña, Kelun Wang, Matteo Castaldo and Lars Arendt-Nielsen

    The Journal of Headache and Pain 2017 18:43

    Published on: 11 April 2017

  12. Research article

    The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis

    Migraine has been recognized as one of the leading causes of disability in the 2013 Global Burden of Disease Study and seriously affects the quality of patients’ life, current treatment options are not ideal. ...

    Min Hou, Haiyan Xing, Yongqing Cai, Bin Li, Xianfeng Wang, Pan Li, Xiaolin Hu and Jianhong Chen

    The Journal of Headache and Pain 2017 18:42

    Published on: 7 April 2017

  13. Research article

    Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity

    Pain catastrophizing (PC) is associated with more severe and disabling migraine attacks. However, factors that moderate this relationship are unknown. Failure of inhibitory control (IC), or the ability to supp...

    Rachel Galioto, Kevin C. O’Leary, J. Graham Thomas, Kathryn Demos, Richard B. Lipton, John Gunstad, Jelena M. Pavlović, Julie Roth, Lucille Rathier and Dale S. Bond

    The Journal of Headache and Pain 2017 18:41

    Published on: 29 March 2017

  14. Research article

    Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)

    Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater ...

    M. Lukács, K. Warfvinge, J. Tajti, F. Fülöp, J. Toldi, L. Vécsei and L. Edvinsson

    The Journal of Headache and Pain 2017 18:39

    Published on: 23 March 2017

  15. Review article

    Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

    Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy...

    Giorgio Sandrini, Roberto De Icco, Cristina Tassorelli, Nicola Smania and Stefano Tamburin

    The Journal of Headache and Pain 2017 18:38

    Published on: 21 March 2017

  16. Research article

    Anxiety and depression symptoms and migraine: a symptom-based approach research

    Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited inform...

    Mario Fernando Prieto Peres, Juliane P. P. Mercante, Patricia R. Tobo, Helder Kamei and Marcelo Eduardo Bigal

    The Journal of Headache and Pain 2017 18:37

    Published on: 21 March 2017

  17. Research article

    Association of excessive daytime sleepiness with migraine and headache frequency in the general population

    Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general popul...

    Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner and Michael Bjørn Russell

    The Journal of Headache and Pain 2017 18:35

    Published on: 20 March 2017

  18. Research article

    Calcitonin gene-related peptide and pain: a systematic review

    Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in mi...

    Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J. Goadsby and Messoud Ashina

    The Journal of Headache and Pain 2017 18:34

    Published on: 16 March 2017

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