Open Access

HLA and disease association

  • Simonetta Trabace
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S109.10194

DOI: 10.1007/s101940070003


The major histocompatibility complex (MHC) is a genetic system of over 70 known genes on the short arm of chromosome 6 and spans about 4 million base pairs of DNA. The high resolution typing of class I and class I MHC genes and the identification of other genes in the region have increased the definition of the genetic basis of immune responses and diseases of unknown etiology such as the autoimmune diseases. In this paper, I review the literature about HLA and migraine.

Key words HLA Disease Antigen Migraine