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  1. Review article

    Family studies to find rare high risk variants in migraine

    Migraine has long been known as a common complex disease caused by genetic and environmental factors. The pathophysiology and the specific genetic susceptibility are poorly understood. Common variants only exp...

    Rikke Dyhr Hansen, Anne Francke Christensen and Jes Olesen

    The Journal of Headache and Pain 2017 18:32

    Published on: 2 March 2017

  2. Research article

    A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine

    DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows su...

    Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L.H. Spierings, Roger K. Cady and Alan M. Rapoport

    The Journal of Headache and Pain 2017 18:31

    Published on: 1 March 2017

  3. Research article

    Increased levels of intramuscular cytokines in patients with jaw muscle pain

    The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with t...

    S. Louca Jounger, N. Christidis, P. Svensson, T. List and M. Ernberg

    The Journal of Headache and Pain 2017 18:30

    Published on: 27 February 2017

  4. Research article

    Primary headache disorders in the adult general population of Pakistan – a cross sectional nationwide prevalence survey

    The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakist...

    A. A. Herekar, A. Ahmad, U. L. Uqaili, B. Ahmed, J. Effendi, S. Z. Alvi, M. A. Shahab, U. Javed, A. D. Herekar, Rafiq Khanani and T. J. Steiner

    The Journal of Headache and Pain 2017 18:28

    Published on: 23 February 2017

  5. Research article

    Depression and anxiety behaviour in a rat model of chronic migraine

    Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals.

    Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong and Shengyuan Yu

    The Journal of Headache and Pain 2017 18:27

    Published on: 21 February 2017

  6. Research article

    Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI

    Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the...

    Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma and Shengyuan Yu

    The Journal of Headache and Pain 2017 18:25

    Published on: 20 February 2017

  7. Research article

    OnabotulinumtoxinA effectiveness on chronic migraine, negative emotional states and sleep quality: a single-center prospective cohort study

    OnabotulinumtoxinA (OnabotA) is considered effective in in patients with chronic migraine (CM) who failed on traditional therapies. This study was designed to evaluate the effect of OnabotA injection series on...

    Elif Ilgaz Aydinlar, Pinar Yalinay Dikmen, Seda Kosak and Ayse Sagduyu Kocaman

    The Journal of Headache and Pain 2017 18:23

    Published on: 17 February 2017

  8. Short report

    Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study

    In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus stan...

    Charly Gaul, Delphine Magis, Eric Liebler and Andreas Straube

    The Journal of Headache and Pain 2017 18:22

    Published on: 14 February 2017

  9. Review article

    Genetic and biochemical changes of the serotonergic system in migraine pathobiology

    Migraine is a brain disorder characterized by a piercing headache which affects one side of the head, located mainly at the temples and in the area around the eye. Migraine imparts substantial suffering to the...

    Claudia Francesca Gasparini, Robert Anthony Smith and Lyn Robyn Griffiths

    The Journal of Headache and Pain 2017 18:20

    Published on: 13 February 2017

  10. Research article

    Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study

    In the emergency setting, non-traumatic headache is a benign symptom in 80% of cases, but serious underlying conditions need to be ruled out.

    Claudine Angela Blum, Bettina Winzeler, Nicole Nigro, Philipp Schuetz, Silke Biethahn, Timo Kahles, Cornelia Mueller, Katharina Timper, Katharina Haaf, Janina Tepperberg, Margareth Amort, Andreas Huber, Roland Bingisser, Peter Stephan Sándor, Krassen Nedeltchev, Beat Müller…

    The Journal of Headache and Pain 2017 18:21

    Published on: 13 February 2017

  11. Research article

    The association of headache frequency with pain interference and the burden of disease is mediated by depression and sleep quality, but not anxiety, in chronic tension type headache

    A better understanding of potential relationship between mood disorders, sleep quality, pain, and headache frequency may assist clinicians in determining optimal therapeutic programs. The aim of the current st...

    María Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Ángel Guerrero-Peral, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

    The Journal of Headache and Pain 2017 18:19

    Published on: 10 February 2017

  12. Short report

    Psychiatric comorbidities and photophobia in patients with migraine

    Based on recent findings and our own impressions we took a closer look at the relationship between (inter)ictal photophobia and psychometric variables in migraine patients with photophobia.

    Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan and Christian Wöber

    The Journal of Headache and Pain 2017 18:18

    Published on: 9 February 2017

    The Erratum to this article has been published in The Journal of Headache and Pain 2017 18:33

  13. Research article

    Randomized, double-blind, crossover study comparing DFN-11 injection (3 mg subcutaneous sumatriptan) with 6 mg subcutaneous sumatriptan for the treatment of rapidly-escalating attacks of episodic migraine

    A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy.

    Roger K. Cady, Sagar Munjal, Ryan J. Cady, Heather R. Manley and Elimor Brand-Schieber

    The Journal of Headache and Pain 2017 18:17

    Published on: 7 February 2017

  14. Research article

    Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system

    Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms.

    Ashley L. Tyburski, Lan Cheng, Soroush Assari, Kurosh Darvish and Melanie B. Elliott

    The Journal of Headache and Pain 2017 18:16

    Published on: 7 February 2017

  15. Research article

    Mindfulness and pharmacological prophylaxis after withdrawal from medication overuse in patients with Chronic Migraine: an effectiveness trial with a one-year follow-up

    Chronic Migraine (CM) is a disabling condition, worsened when associated with Medication Overuse (MO). Mindfulness is an emerging technique, effective in different pain conditions, but it has yet to be explore...

    Licia Grazzi, Emanuela Sansone, Alberto Raggi, Domenico D’Amico, Andrea De Giorgio, Matilde Leonardi, Laura De Torres, Francisco Salgado-García and Frank Andrasik

    The Journal of Headache and Pain 2017 18:15

    Published on: 4 February 2017

  16. Review article

    The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis

    Migraine is a recurrent headache disease related to genetic variants. The brain-derived neurotrophic factor (BDNF) gene rs6265 (Val66Met) and rs2049046 polymorphism has been found to be associated with migrain...

    Xiaoying Cai, Xiaolei Shi, Ximeng Zhang, Aiwu Zhang, Minying Zheng and Yannan Fang

    The Journal of Headache and Pain 2017 18:13

    Published on: 2 February 2017

  17. Research article

    Volume gain of periaqueductal gray in medication-overuse headache

    Periaqueductal gray (PAG) is a substantial descending pain modulatory center, and previous voxel-based morphometry study confirmed the clusters with increased volume in PAG region in medication-overuse headach...

    Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

    The Journal of Headache and Pain 2017 18:12

    Published on: 1 February 2017

  18. Erratum

    The Journal of Headache and Pain 2017 18:11

    Published on: 31 January 2017

    The original article was published in The Journal of Headache and Pain 2015 16:A52

    The original article was published in The Journal of Headache and Pain 2015 16:A160

    The original article was published in The Journal of Headache and Pain 2015 16:A87

    The original article was published in The Journal of Headache and Pain 2015 16:A1

    The original article was published in The Journal of Headache and Pain 2015 16:A49

    The original article was published in The Journal of Headache and Pain 2015 16:A106

    The original article was published in The Journal of Headache and Pain 2015 16:A99

    The original article was published in The Journal of Headache and Pain 2015 16:A90

    The original article was published in The Journal of Headache and Pain 2015 16:A54

    The original article was published in The Journal of Headache and Pain 2015 16:A91

    The original article was published in The Journal of Headache and Pain 2015 16:A59

    The original article was published in The Journal of Headache and Pain 2015 16:A158

    The original article was published in The Journal of Headache and Pain 2015 16:A55

    The original article was published in The Journal of Headache and Pain 2015 16:A58

  19. Short report

    Endovascular thrombectomy and post-procedural headache

    We investigated the prevalence of post-procedural headache in patients who have undergone thrombectomy for ischemic stroke, and correlated history of migraine with risk of peri-procedural complications. A tota...

    Sabrina Khan, Faisal Mohammad Amin, Markus Holtmannspötter, Klaus Hansen, Anna Maria Florescu, Zainab Fakhril-Din, Julie Falkenberg Petersen, Hashmat Ghanizada, Cenk Ayata, David Gaist and Messoud Ashina

    The Journal of Headache and Pain 2017 18:10

    Published on: 28 January 2017

  20. Research article

    Simulated airplane headache: a proxy towards identification of underlying mechanisms

    Airplane Headache (AH) occurs during flights and often appears as an intense, short lasting headache during take-off or landing. Reports are limited on pathological mechanisms underlying the occurrence of this...

    Sebastian Bao Dinh Bui, Torben Petersen, Jeppe Nørgaard Poulsen and Parisa Gazerani

    The Journal of Headache and Pain 2017 18:9

    Published on: 28 January 2017

  21. Research article

    Interictal brain activity differs in migraine with and without aura: resting state fMRI study

    Migraine is one of the most severe primary headache disorders. The nature of the headache and the associated symptoms during the attack suggest underlying functional alterations in the brain. In this study, we...

    Péter Faragó, Bernadett Tuka, Eszter Tóth, Nikoletta Szabó, András Király, Gergő Csete, Délia Szok, János Tajti, Árpád Párdutz, László Vécsei and Zsigmond Tamás Kincses

    The Journal of Headache and Pain 2017 18:8

    Published on: 25 January 2017

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