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  1. Research article

    The course of headache in patients with moderate-to-severe headache due to mild traumatic brain injury: a retrospective cross-sectional study

    Little is known about the long-term course of headache in patients with moderate-to-severe headache due to traumatic brain injury (TBI). We evaluated the course of headache in patients with moderate-to-severe...

    Chang-Ki Hong, Jin-Yang Joo, Yu Shik Shim, Sook Young Sim, Min A Kwon, Yong Bae Kim and Joonho Chung

    The Journal of Headache and Pain 2017 18:48

    Published on: 20 April 2017

  2. Research article

    Restless legs syndrome and tension-type headache: a population-based study

    Recent studies have shown a significant association between restless legs syndrome (RLS) and primary headache disorders. Nevertheless, information regarding the association between tension-type headache (TTH) ...

    Pil-Wook Chung, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

    The Journal of Headache and Pain 2017 18:47

    Published on: 19 April 2017

  3. Research article

    Level of physical activity, well-being, stress and self-rated health in persons with migraine and co-existing tension-type headache and neck pain

    The prevalence of migraine with co-existing tension-type headache and neck pain is high in the general population. However, there is very little literature on the characteristics of these combined conditions. ...

    Lotte Skytte Krøll, Catharina Sjödahl Hammarlund, Maria Lurenda Westergaard, Trine Nielsen, Louise Bönsdorff Sloth, Rigmor Højland Jensen and Gunvor Gard

    The Journal of Headache and Pain 2017 18:46

    Published on: 18 April 2017

  4. Research article

    Identification of subgroups of patients with tension type headache with higher widespread pressure pain hyperalgesia

    Identification of subgroups of patients with different levels of sensitization and clinical features can help to identify groups at risk and the development of better therapeutic strategies. The aim of this st...

    César Fernández-de-las-Peñas, Elena Benito-González, María Palacios-Ceña, Kelun Wang, Matteo Castaldo and Lars Arendt-Nielsen

    The Journal of Headache and Pain 2017 18:43

    Published on: 11 April 2017

  5. Research article

    The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis

    Migraine has been recognized as one of the leading causes of disability in the 2013 Global Burden of Disease Study and seriously affects the quality of patients’ life, current treatment options are not ideal. ...

    Min Hou, Haiyan Xing, Yongqing Cai, Bin Li, Xianfeng Wang, Pan Li, Xiaolin Hu and Jianhong Chen

    The Journal of Headache and Pain 2017 18:42

    Published on: 7 April 2017

  6. Research article

    Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity

    Pain catastrophizing (PC) is associated with more severe and disabling migraine attacks. However, factors that moderate this relationship are unknown. Failure of inhibitory control (IC), or the ability to supp...

    Rachel Galioto, Kevin C. O’Leary, J. Graham Thomas, Kathryn Demos, Richard B. Lipton, John Gunstad, Jelena M. Pavlović, Julie Roth, Lucille Rathier and Dale S. Bond

    The Journal of Headache and Pain 2017 18:41

    Published on: 29 March 2017

  7. Research article

    Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)

    Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater ...

    M. Lukács, K. Warfvinge, J. Tajti, F. Fülöp, J. Toldi, L. Vécsei and L. Edvinsson

    The Journal of Headache and Pain 2017 18:39

    Published on: 23 March 2017

  8. Review article

    Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

    Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy...

    Giorgio Sandrini, Roberto De Icco, Cristina Tassorelli, Nicola Smania and Stefano Tamburin

    The Journal of Headache and Pain 2017 18:38

    Published on: 21 March 2017

  9. Research article

    Anxiety and depression symptoms and migraine: a symptom-based approach research

    Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited inform...

    Mario Fernando Prieto Peres, Juliane P. P. Mercante, Patricia R. Tobo, Helder Kamei and Marcelo Eduardo Bigal

    The Journal of Headache and Pain 2017 18:37

    Published on: 21 March 2017

  10. Research article

    Association of excessive daytime sleepiness with migraine and headache frequency in the general population

    Some previous studies have postulated an association between migraine and excessive daytime sleepiness (EDS). This study evaluated the association of EDS with migraine and headache frequency in a general popul...

    Knut Stavem, Håvard Anton Kristiansen, Espen Saxhaug Kristoffersen, Kari Jorunn Kværner and Michael Bjørn Russell

    The Journal of Headache and Pain 2017 18:35

    Published on: 20 March 2017

  11. Research article

    Calcitonin gene-related peptide and pain: a systematic review

    Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in mi...

    Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J. Goadsby and Messoud Ashina

    The Journal of Headache and Pain 2017 18:34

    Published on: 16 March 2017

  12. Review article

    Family studies to find rare high risk variants in migraine

    Migraine has long been known as a common complex disease caused by genetic and environmental factors. The pathophysiology and the specific genetic susceptibility are poorly understood. Common variants only exp...

    Rikke Dyhr Hansen, Anne Francke Christensen and Jes Olesen

    The Journal of Headache and Pain 2017 18:32

    Published on: 2 March 2017

  13. Research article

    A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine

    DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows su...

    Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L.H. Spierings, Roger K. Cady and Alan M. Rapoport

    The Journal of Headache and Pain 2017 18:31

    Published on: 1 March 2017

  14. Research article

    Increased levels of intramuscular cytokines in patients with jaw muscle pain

    The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with t...

    S. Louca Jounger, N. Christidis, P. Svensson, T. List and M. Ernberg

    The Journal of Headache and Pain 2017 18:30

    Published on: 27 February 2017

  15. Research article

    Primary headache disorders in the adult general population of Pakistan – a cross sectional nationwide prevalence survey

    The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakist...

    A. A. Herekar, A. Ahmad, U. L. Uqaili, B. Ahmed, J. Effendi, S. Z. Alvi, M. A. Shahab, U. Javed, A. D. Herekar, Rafiq Khanani and T. J. Steiner

    The Journal of Headache and Pain 2017 18:28

    Published on: 23 February 2017

  16. Research article

    Depression and anxiety behaviour in a rat model of chronic migraine

    Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals.

    Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong and Shengyuan Yu

    The Journal of Headache and Pain 2017 18:27

    Published on: 21 February 2017

  17. Research article

    Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI

    Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the...

    Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma and Shengyuan Yu

    The Journal of Headache and Pain 2017 18:25

    Published on: 20 February 2017

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