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The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

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Page 1 of 95
  1. Content type: Research article

    In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificit...

    Authors: Charmaine E. Pollock, Heidi G. Sutherland, Bridget H. Maher, Rodney A. Lea, Larisa M. Haupt, Alison Frith, E. Anne MacGregor and Lyn R. Griffiths

    Citation: The Journal of Headache and Pain 2018 19:31

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  2. Content type: Review article

    The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing. T...

    Authors: Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen and Thomas Folkmann Hansen

    Citation: The Journal of Headache and Pain 2018 19:29

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  3. Content type: Review article

    Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularl...

    Authors: Takahiro Hirabayashi, Tomoya Nakamachi and Seiji Shioda

    Citation: The Journal of Headache and Pain 2018 19:28

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  4. Content type: Research article

    Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy.

    Authors: Beáta Éva Petrovski, Kjersti G. Vetvik, Christofer Lundqvist and Malin Eberhard-Gran

    Citation: The Journal of Headache and Pain 2018 19:27

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  5. Content type: Research article

    The primary aim of this cross-sectional population-based study was to evaluate the 1-year prevalence of common headache disorders by a face-to-face interview.

    Authors: Knut Hagen, Anders Nikolai Åsberg, Benjamin L. Uhlig, Erling Tronvik, Eiliv Brenner, Marit Stjern, Grethe Helde, Gøril Bruvik Gravdahl and Trond Sand

    Citation: The Journal of Headache and Pain 2018 19:25

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  6. Content type: Research article

    Migraineurs have a high prevalence of neck pain prior to or during headache attacks. Whether neck pain is a symptom of migraine or an indicator for a constant neck muscle dysfunction potentially triggering mig...

    Authors: Kerstin Luedtke, Jan Mehnert and Arne May

    Citation: The Journal of Headache and Pain 2018 19:26

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  7. Content type: Research article

    The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divid...

    Authors: Yu-Jie Dai, Xin Zhang, Yang Yang, Hai-Yan Nan, Ying Yu, Qian Sun, Lin-Feng Yan, Bo Hu, Jin Zhang, Zi-Yu Qiu, Yi Gao, Guang-Bin Cui, Bi-Liang Chen and Wen Wang

    Citation: The Journal of Headache and Pain 2018 19:24

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  8. Content type: Review article

    The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients ha...

    Authors: James A. Waschek, Serapio M. Baca and Simon Akerman

    Citation: The Journal of Headache and Pain 2018 19:23

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  9. Content type: Review article

    Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

    Authors: Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

    Citation: The Journal of Headache and Pain 2018 19:21

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  10. Content type: Review article

    Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

    Authors: Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2018 19:19

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  11. Content type: Research article

    Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups h...

    Authors: Christian Wöber, Çiçek Wöber-Bingöl, Derya Uluduz, Tuna Stefan Aslan, Uğur Uygunoglu, Ahmet Tüfekçi, Selen Ilhan Alp, Taşkın Duman, Fidan Sürgün, Gülser Karadaban Emir, Caner Feyzi Demir, Ferhat Balgetir, Yeliz Bahar Özdemir, Tanja Auer, Aksel Siva and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:18

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  12. Content type: Review article

    In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

    Authors: Inger Jansen-Olesen and Sara Hougaard Pedersen

    Citation: The Journal of Headache and Pain 2018 19:16

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  13. Content type: Methodology

    Headache disorders are both common and burdensome but, given the many people affected, provision of health care to all is challenging. Structured headache services based in primary care are the most efficient,...

    Authors: T. J. Steiner, D. C. Buse, M. Al Jumah, M. L. Westergaard, R. H. Jensen, M. L. Reed, L. Prilipko, F. S. Mennini, M. J. A. Láinez, K. Ravishankar, F. Sakai, S.-Y. Yu, M. Fontebasso, A. Al Khathami, E. A. MacGregor, F. Antonaci…

    Citation: The Journal of Headache and Pain 2018 19:15

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  14. Content type: Research article

    Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sp...

    Authors: Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug and Erling Tronvik

    Citation: The Journal of Headache and Pain 2018 19:14

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  15. Content type: Research article

    OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable.

    Authors: Andrew M. Blumenfeld, Richard J. Stark, Marshall C. Freeman, Amelia Orejudos and Aubrey Manack Adams

    Citation: The Journal of Headache and Pain 2018 19:13

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  16. Content type: Research article

    Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine p...

    Authors: Katrine Falkenberg, Bára Óladóttir á Dunga, Song Guo, Messoud Ashina and Jes Olesen

    Citation: The Journal of Headache and Pain 2018 19:11

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  17. Content type: Methodology

    The burden attributable to headache disorders has multiple components: a simple measure summarising them all does not exist. The Migraine Disability Assessment (MIDAS) instrument has proved useful, estimating ...

    Authors: T. J. Steiner and R. B. Lipton

    Citation: The Journal of Headache and Pain 2018 19:12

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  18. Content type: Research article

    Migraine is prevalent everywhere, and disabling. It is also neglected: consequently, it is under-diagnosed and undertreated. We analysed data from the Eurolight study on consultations and utilization of migrai...

    Authors: Zaza Katsarava, Maka Mania, Christian Lampl, Johanna Herberhold and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2018 19:10

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