The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

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  1. Research article

    Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures

    The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divid...

    Yu-Jie Dai, Xin Zhang, Yang Yang, Hai-Yan Nan, Ying Yu, Qian Sun, Lin-Feng Yan, Bo Hu, Jin Zhang, Zi-Yu Qiu, Yi Gao, Guang-Bin Cui, Bi-Liang Chen and Wen Wang

    The Journal of Headache and Pain 2018 19:24

    Published on: 14 March 2018

  2. Review article

    PACAP and its role in primary headaches

    Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observ...

    Lars Edvinsson, János Tajti, Levente Szalárdy and László Vécsei

    The Journal of Headache and Pain 2018 19:21

    Published on: 9 March 2018

  3. Review article

    Protective effects of PACAP in ischemia

    Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Prese...

    Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran and Antoinette MaassenVanDenBrink

    The Journal of Headache and Pain 2018 19:19

    Published on: 2 March 2018

  4. Research article

    Undifferentiated headache: broadening the approach to headache in children and adolescents, with supporting evidence from a nationwide school-based cross-sectional survey in Turkey

    Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups h...

    Christian Wöber, Çiçek Wöber-Bingöl, Derya Uluduz, Tuna Stefan Aslan, Uğur Uygunoglu, Ahmet Tüfekçi, Selen Ilhan Alp, Taşkın Duman, Fidan Sürgün, Gülser Karadaban Emir, Caner Feyzi Demir, Ferhat Balgetir, Yeliz Bahar Özdemir, Tanja Auer, Aksel Siva and Timothy J. Steiner

    The Journal of Headache and Pain 2018 19:18

    Published on: 27 February 2018

  5. Review article

    PACAP and its receptors in cranial arteries and mast cells

    In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion ...

    Inger Jansen-Olesen and Sara Hougaard Pedersen

    The Journal of Headache and Pain 2018 19:16

    Published on: 20 February 2018

  6. Methodology

    The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility

    Headache disorders are both common and burdensome but, given the many people affected, provision of health care to all is challenging. Structured headache services based in primary care are the most efficient,...

    T. J. Steiner, D. C. Buse, M. Al Jumah, M. L. Westergaard, R. H. Jensen, M. L. Reed, L. Prilipko, F. S. Mennini, M. J. A. Láinez, K. Ravishankar, F. Sakai, S.-Y. Yu, M. Fontebasso, A. Al Khathami, E. A. MacGregor, F. Antonaci…

    The Journal of Headache and Pain 2018 19:15

    Published on: 14 February 2018

  7. Research article

    Measurement and implications of the distance between the sphenopalatine ganglion and nasal mucosa: a neuroimaging study

    Historical reports describe the sphenopalatine ganglion (SPG) as positioned directly under the nasal mucosa. This is the basis for the topical intranasal administration of local anaesthetic (LA) towards the sp...

    Joan Crespi, Daniel Bratbak, David Dodick, Manjit Matharu, Kent Are Jamtøy, Irina Aschehoug and Erling Tronvik

    The Journal of Headache and Pain 2018 19:14

    Published on: 13 February 2018

  8. Research article

    Long-term study of the efficacy and safety of OnabotulinumtoxinA for the prevention of chronic migraine: COMPEL study

    OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable.

    Andrew M. Blumenfeld, Richard J. Stark, Marshall C. Freeman, Amelia Orejudos and Aubrey Manack Adams

    The Journal of Headache and Pain 2018 19:13

    Published on: 5 February 2018

  9. Research article

    Cilostazol induced migraine does not respond to sumatriptan in a double blind trial

    Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine p...

    Katrine Falkenberg, Bára Óladóttir á Dunga, Song Guo, Messoud Ashina and Jes Olesen

    The Journal of Headache and Pain 2018 19:11

    Published on: 2 February 2018

  10. Research article

    Headache following head injury: a population-based longitudinal cohort study (HUNT)

    Headache is the most frequent symptom following head injury, but long-term follow-up of headache after head injury entails methodological challenges. In a population-based cohort study, we explored whether sub...

    Lena Hoem Nordhaug, Knut Hagen, Anne Vik, Lars Jacob Stovner, Turid Follestad, Torunn Pedersen, Gøril Bruvik Gravdahl and Mattias Linde

    The Journal of Headache and Pain 2018 19:8

    Published on: 22 January 2018

  11. Research article

    PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

    Pyruvate kinase isozymes M2 (PKM2), as a member of pyruvate kinase family, plays a role of glycolytic enzyme in glucose metabolism. It also functions as protein kinase in cell proliferation, signaling, immunit...

    Binbin Wang, Siyuan Liu, Bingbing Fan, Xingguo Xu, Yonglin Chen, Rongxiang Lu, Zhongling Xu and Xiaojuan Liu

    The Journal of Headache and Pain 2018 19:7

    Published on: 18 January 2018

  12. Research article

    Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry

    Cluster headache (CH) is a disabling primary headache disorder characterized by severe periorbital pain. A subset of patients does not respond to established pharmacological therapy. This study examines outcom...

    Mads Barloese, Anja Petersen, Philipp Stude, Tim Jürgens, Rigmor Højland Jensen and Arne May

    The Journal of Headache and Pain 2018 19:6

    Published on: 18 January 2018

  13. Research article

    Treatment of disabling headache with greater occipital nerve injections in a large population of childhood and adolescent patients: a service evaluation

    Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with ...

    Francesca Puledda, Peter J. Goadsby and Prab Prabhakar

    The Journal of Headache and Pain 2018 19:5

    Published on: 16 January 2018

  14. Research article

    Comparison of gray matter volume between migraine and “strict-criteria” tension-type headache

    Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both t...

    Wei-Ta Chen, Kun-Hsien Chou, Pei-Lin Lee, Fu-Jung Hsiao, David M. Niddam, Kuan-Lin Lai, Jong-Ling Fuh, Ching-Po Lin and Shuu-Jiun Wang

    The Journal of Headache and Pain 2018 19:4

    Published on: 15 January 2018

  15. Research article

    Effect of a calcitonin gene-related peptide-binding L-RNA aptamer on neuronal activity in the rat spinal trigeminal nucleus

    Calcitonin gene-related peptide (CGRP) plays a major role in the pathogenesis of migraine and other primary headaches. Spinal trigeminal neurons integrate nociceptive afferent input from trigeminal tissues inc...

    Michael J. M. Fischer, Jakob Schmidt, Stanislav Koulchitsky, Sven Klussmann, Axel Vater and Karl Messlinger

    The Journal of Headache and Pain 2018 19:3

    Published on: 15 January 2018

  16. Research article

    Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study

    Cluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirme...

    Zhiliang Fan, Lei Hou, Dongjun Wan, Ran Ao, Dengfa Zhao and Shengyuan Yu

    The Journal of Headache and Pain 2018 19:1

    Published on: 9 January 2018

  17. Research article

    The burden of headache is associated to pain interference, depression and headache duration in chronic tension type headache: a 1-year longitudinal study

    To investigate variables associated at one year (longitudinal design) with the physical or emotional component of burden in chronic tension type headache (CTTH).

    Stella Fuensalida-Novo, Maria Palacios-Ceña, Juan J. Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Antonella Catena, Lars Arendt-Nielsen and César Fernández-de-las-Peñas

    The Journal of Headache and Pain 2017 18:119

    Published on: 28 December 2017

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