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  1. Consensus article

    Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)

    Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migra...

    Simona Sacco, Gabriele S. Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E. Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Per Morten Sandset and Paolo Martelletti

    The Journal of Headache and Pain 2017 18:108

    Published on: 30 October 2017

  2. Review article

    Caffeine in the management of patients with headache

    Caffeinated headache medications, either alone or in combination with other treatments, are widely used by patients with headache. Clinicians should be familiar with their use as well as the chemistry, pharmac...

    Richard B. Lipton, Hans-Christoph Diener, Matthew S. Robbins, Sandy Yacoub Garas and Ketu Patel

    The Journal of Headache and Pain 2017 18:107

    Published on: 24 October 2017

  3. Review article

    Headache and pregnancy: a systematic review

    This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child ...

    A. Negro, Z. Delaruelle, T. A. Ivanova, S. Khan, R. Ornello, B. Raffaelli, A. Terrin, U. Reuter and D. D. Mitsikostas

    The Journal of Headache and Pain 2017 18:106

    Published on: 19 October 2017

  4. Research article

    Burden of migraine in a Kuwaiti population: a door-to-door survey

    Migraine prevalence and disability imprints on Kuwaiti population are underreported. We aimed to measure the prevalence of migraine and to assess its burden in Kuwait.

    Jasem Yousef Al-Hashel, Samar Farouk Ahmed and Raed Alroughani

    The Journal of Headache and Pain 2017 18:105

    Published on: 13 October 2017

  5. Research article

    The role of α1- and α2-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats

    Dihydroergotamine (DHE) is an acute antimigraine agent that displays affinity for dopamine D2-like receptors, serotonin 5-HT1/2 receptors and α12-adrenoceptors. Since activation of vascular α12-adrenoceptors ...

    Eduardo Rivera-Mancilla, Victor H. Avilés-Rosas, Guadalupe Manrique-Maldonado, Alain H. Altamirano-Espinoza, Belinda Villanueva-Castillo, Antoinette MaassenVanDenBrink and Carlos M. Villalón

    The Journal of Headache and Pain 2017 18:104

    Published on: 11 October 2017

  6. Review article

    Triptans and CGRP blockade – impact on the cranial vasculature

    The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including seroton...

    Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Anne Luise Vollesen, Christian Lampl and Messoud Ashina

    The Journal of Headache and Pain 2017 18:103

    Published on: 10 October 2017

  7. Research article

    Patients’ preferences for headache acute and preventive treatment

    We aimed to explore patients’ preferences for headache treatments with a self-administered questionnaire including the Q-No questionnaire for nocebo.

    Dimos D. Mitsikostas, Ioanna Belesioti, Chryssa Arvaniti, Euthymia Mitropoulou, Christina Deligianni, Elina Kasioti, Theodoros Constantinidis, Manolis Dermitzakis and Michail Vikelis

    The Journal of Headache and Pain 2017 18:102

    Published on: 6 October 2017

  8. Research article

    Fluctuations in episodic and chronic migraine status over the course of 1 year: implications for diagnosis, treatment and clinical trial design

    Relatively little is known about the stability of a diagnosis of episodic migraine (EM) or chronic migraine (CM) over time. This study examines natural fluctuations in self-reported headache frequency as well ...

    Daniel Serrano, Richard B. Lipton, Ann I. Scher, Michael L. Reed, Walter (Buzz) F. Stewart, Aubrey Manack Adams and Dawn C. Buse

    The Journal of Headache and Pain 2017 18:101

    Published on: 4 October 2017

  9. Research article

    Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study

    Migraineurs seem to have cyclic variations in cortical excitability in several neurophysiological modalities. Laser-evoked potentials (LEP) are of particular interest in migraine because LEP specifically targe...

    Martin Uglem, Petter Moe Omland, Marit Stjern, Gøril Bruvik Gravdahl and Trond Sand

    The Journal of Headache and Pain 2017 18:100

    Published on: 2 October 2017

  10. Research article

    Assessing and treating primary headaches and cranio-facial pain in patients undergoing rehabilitation for neurological diseases

    Pain is a very common condition in patient undergoing rehabilitation for neurological disease; however the presence of primary headaches and other cranio-facial pains, particularly when they are actually or ap...

    Cristina Tassorelli, Marco Tramontano, Mariangela Berlangieri, Vittorio Schweiger, Mariagrazia D’Ippolito, Valerio Palmerini, Sara Bonazza, Riccardo Rosa, Rosanna Cerbo and Maria Gabriella Buzzi

    The Journal of Headache and Pain 2017 18:99

    Published on: 29 September 2017

  11. Research article

    Brain networking analysis in migraine with and without aura

    To apply effective connectivity by means of nonlinear Granger Causality (GC) and brain networking analysis to basal EEG and under visual stimulation by checkerboard gratings with 0.5 and 2.0 cpd as spatial fre...

    Marina de Tommaso, Gabriele Trotta, Eleonora Vecchio, Katia Ricci, R. Siugzdaite and Sebastiano Stramaglia

    The Journal of Headache and Pain 2017 18:98

    Published on: 29 September 2017

  12. Review article

    Blocking CGRP in migraine patients – a review of pros and cons

    Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than mi...

    Marie Deen, Edvige Correnti, Katharina Kamm, Tim Kelderman, Laura Papetti, Eloisa Rubio-Beltrán, Simone Vigneri, Lars Edvinsson and Antoinette Maassen Van Den Brink

    The Journal of Headache and Pain 2017 18:96

    Published on: 25 September 2017

  13. Research article

    Insomnia in tension-type headache: a population-based study

    Tension-type headache (TTH) represents the most common type of headache among the general population. Although such headaches are usually mild in severity, some individuals with TTH experience severe symptoms ...

    Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun and Min Kyung Chu

    The Journal of Headache and Pain 2017 18:95

    Published on: 12 September 2017

  14. Research article

    The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model

    Clinical and experimental studies have pointed to the possible involvement of the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this study, we aimed to further investigate t...

    Chiara Demartini, Cristina Tassorelli, Anna Maria Zanaboni, Germana Tonsi, Oscar Francesconi, Cristina Nativi and Rosaria Greco

    The Journal of Headache and Pain 2017 18:94

    Published on: 7 September 2017

  15. Research article

    Real-life use of onabotulinumtoxinA for symptom relief in patients with chronic migraine: REPOSE study methodology and baseline data

    Migraine is a debilitating neurological disorder that affects 14.1% of the US and 14.7% of the European populations. Chronic migraine (CM) is broadly defined as headache occurring on ≥15 days per month for ≥3 ...

    Brendan Davies, Charly Gaul, Paolo Martelletti, Juan Carlos García-Moncó and Stephanie Brown

    The Journal of Headache and Pain 2017 18:93

    Published on: 6 September 2017

  16. Letter to the Editor

    Correspondence regarding: Post-traumatic headache: the use of the sport concussion assessment tool (SCAT-3) as a predictor of post-concussion recovery

    This article consists of a Letter to the Editor regarding Post-traumatic headache: the use of the sport concussion assessment tool (SCAT-3) as a predictor of post-concussion recovery, recently published in The Jo...

    Salman Khazaei, Shiva Mansouri Hanis, Kamyar Mansori, Olivia Begasse de Dhaem, William B. Barr, Laura J. Balcer, Steven L. Galetta and Mia T. Minen

    The Journal of Headache and Pain 2017 18:92

    Published on: 31 August 2017

  17. Research article

    Temporal relations in hormone-withdrawal migraines and impact on prevention- a diary-based pilot study in combined hormonal contraceptive users

    Menstrually related migraine (MRM) in the hormone-free interval (HFI) of combined hormonal contraceptives (CHC) are according to the ICHD definition also estrogen withdrawal migraines (EWH). MRMs are less resp...

    Gabriele S. Merki-Feld, Gina Epple, Nina Caveng, Bruno Imthurn, Burkhardt Seifert, Peter Sandor and Andreas R. Gantenbein

    The Journal of Headache and Pain 2017 18:91

    Published on: 25 August 2017

  18. Research article

    Altered insula–default mode network connectivity in fibromyalgia: a resting-state magnetoencephalographic study

    Fibromyalgia (FM) is a disabling chronic pain syndrome with unknown pathophysiology. Functional magnetic resonance imaging studies on FM have suggested altered brain connectivity between the insula and the def...

    Fu-Jung Hsiao, Shuu-Jiun Wang, Yung-Yang Lin, Jong-Ling Fuh, Yu-Chieh Ko, Pei-Ning Wang and Wei-Ta Chen

    The Journal of Headache and Pain 2017 18:89

    Published on: 23 August 2017

  19. Review article

    The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

    To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.

    Mohammad Al-Mahdi Al-Karagholi, Jakob Møller Hansen, Johanne Severinsen, Inger Jansen-Olesen and Messoud Ashina

    The Journal of Headache and Pain 2017 18:90

    Published on: 23 August 2017

  20. Research article

    Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure

    The majority of individuals with post-traumatic headache have symptoms that are indistinguishable from migraine. The overlap in symptoms amongst these individuals raises the question as to whether post-traumat...

    Todd J. Schwedt, Catherine D. Chong, Jacob Peplinski, Katherine Ross and Visar Berisha

    The Journal of Headache and Pain 2017 18:87

    Published on: 22 August 2017

  21. Research article

    Screening of genetic variants in ADCYAP1R1, MME and 14q21 in a Swedish cluster headache cohort

    We have genotyped a Swedish cluster headache case-control population for three genetic variants representing the most significant markers identified in a recently published genome wide association study on clu...

    Caroline Ran, Carmen Fourier, Julia M. Michalska, Anna Steinberg, Christina Sjöstrand, Elisabet Waldenlind and Andrea Carmine Belin

    The Journal of Headache and Pain 2017 18:88

    Published on: 22 August 2017

  22. Short report

    Excessive daytime sleepiness in secondary chronic headache from the general population

    Excessive daytime sleepiness (EDS, defined as Epworth sleepiness scale score > 10) is a common symptom, with a prevalence of 10–20% in the general population. It is associated with headache and other chronic p...

    Espen Saxhaug Kristoffersen, Knut Stavem, Christofer Lundqvist and Michael Bjørn Russell

    The Journal of Headache and Pain 2017 18:85

    Published on: 16 August 2017

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