Open Access

Beneficial effects of Helicobacter pylori eradication on migraine: a 12-month follow-up study

  • Maurizio Gabrielli,
  • Francesco Franceschi,
  • Giuseppe Fiore,
  • Marcello Candelli,
  • Alessandro Armuzzi,
  • Veronica Ojetti,
  • Filippo Cremonini,
  • Paolo Pola,
  • Mario Giacovazzo and
  • Antonio Gasbarrini
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches2:10020039.10194


Helicobacter pylori (H. pylori) has been recently associated with some organic and functional vascular disorders. In particular, our group found a high prevalence of H. pylori in patients affected by migraine and a significant improvement of migraine symptoms after eradication of the bacterium, during a follow-up period of 6 months. However, seasonal variations may affect clinical manifestations of migraine, thus influencing our previous results. The present study evaluated the effect of H. pylori eradication during a 1-year follow-up period in a population of 148 consecutively enrolled migraine patients. H. pylori infection was assessed by 13C-urea breath test. Infected subjects underwent specific antibiotic treatment in order to eradiate the bactrium. Frequency, intensity and duration of attacks of migraine were assessed during a 1-year follow-up period. 42% of the patients showed H. pylori infection. 82% resulted eradicated. Interestingly, 28% of the patietns reported a disappearance of migraine during the follow-up period. Moreover, a significant decrease of intensity, frequency and duration of the migraine attacks evaluated 2, 4, 6 and 12 months from H. pylori eradication was observed in the remaining patients. The beneficial effects of H. pylori eradication on migraine seem to be confirmed by this prolonged 1-year follow-up study.

Key wordsHelicobacter pyloriMigraineCytotoxinsVasopasm