Open Access

Successful treatment of indomethacin-intolerant chronic paroxysmal hemicrania: report of two cases

The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches4:53

Received: 23 May 2003

Accepted: 17 July 2003


Chronic paroxysmal hemicrania (CPH) is a rare headache syndrome resulting in non-remitting, recurrent, intense, short-lasting pain, with typical, often total, responsiveness to indomethacin. Other drugs have anecdotally been reported to be potentially effective. Apparent unreponsiveness, in fact due to intolerance to this non-steroidal antiinflammatory drug, can lead to doubt about the initial diagnosis. Two such cases of CPH, for whom effective alternative treatment was eventually given, are described.

Key words

Chronic paroxysmal hemicraniaIndomethacinCarbamazepineVerapamilKetoprofen