Open Access

Migraine associated with facial ecchymoses ipsilateral to the symptomatic side

  • Donato Nozzolillo1,
  • Claudio Negro1,
  • Cecilia Nozzoli1,
  • Augusto de Rini1,
  • Vincenzo Marco1 and
  • Bruno Passarella1Email author
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches5:136

Received: 8 March 2004

Accepted: 12 July 2004


The following is the case of a 55-year-old woman showing palpebral ecchymoses ipsilateral to the symptomatic side during migraine episodes. The lesions are not associated with oedema or other vegetative manifestations. A possible pathogenic mechanism hypothesised is a dermal diapedesis of erythrocytes due to neurogenic inflammation following trigeminovascular activation during migraine crises.

Key words

MigrainePalpebral ecchymoses