Open Access

Genetic risk factors in primary paediatric versus adult headache: complexities and problematics

  • V. Lisi1, 2,
  • G. Garbo3,
  • F. Miccichè1, 2,
  • A. Stecca1, 2,
  • S. Terrazzino1, 2,
  • M. Franzoi3,
  • E. Tripoli3,
  • M. Clementi3,
  • A. Leon1, 2 and
  • P. A. Battistella3Email author
The Journal of Headache and Pain20056:178

Published: 20 July 2005


Numerous candidate genes for migraine have been proposed on the basis of their possible functional role in its pathogenesis. Genetic polymorphisms have been evaluated in association studies, some of which have been suggested to be susceptibility markers for adult migraine. To date, however, none of the identified polymorphisms in adult migraine susceptibility have been investigated in children, raising the possibility that they may not be necessarily involved in paediatric migraine susceptibility. This paper reviews studies of the genetic basis of migraine and summarises our experience in genetic association studies in primary paediatric headache susceptibility.

Key words

Paediatric migraineSusceptibilityPolymorphismEndothelin type A receptor