The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

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Open Access

Headache in patients with chronic obstructive pulmonary disease: effects of chronic hypoxaemia

  • A. Özge1, 3Email author,
  • C. Özge2,
  • H. Kaleagasi1,
  • O. Ö. Yalin1,
  • Ö. Ünal1 and
  • E. S. Özgür2
The Journal of Headache and Pain20067:264

Received: 28 September 2005

Accepted: 11 December 2005

Published: 17 January 2006


The frequency and characteristics of headache in patients with chronic obstructive pulmonary disease (COPD) are not clear and there are only a few studies that have assessed the relationship between chronic hypoxaemia and headache. We performed this study in order to evaluate the frequency and characteristics of headache in COPD patients. A total of 119 patients, with a mean age of 63.4 ± 8.2 years, diagnosed with moderate or severe stable COPD were included in the study. Overall 31.9% of the patients complained of headache and 45.4% were reported to have sleep disorders. There were significant effects of family history of COPD, having other systemic disorders or sleep disorders (snoring, bruxism, restless leg syndrome, etc.) and laboratory data of chronic hypoxaemia and airway obstruction on headache co–morbidity. In conclusion, possibly being a specific subtype of elderly headache, headache in patients with moderate or severe COPD is a common problem and future studies are needed to obtain more knowledge about its pathophysiological and clinical basis.

Key words

Chronic obstructive pulmonary diseaseHeadacheChronic hypoxaemiaSleep disordersPulmonary function tests


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