The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image
Open Access

Cluster headache attacks and multiple sclerosis

  • Salvatore Gentile1Email author,
  • Margherita Ferrero1,
  • Giovanna Vaula1,
  • Innocenzo Rainero1 and
  • Lorenzo Pinessi1
The Journal of Headache and PainOfficial Journal of the European Headache Federation20078:405

Received: 20 March 2007

Accepted: 3 July 2007

Published: 24 September 2007


We report the case of a patient who developed typical cluster headache attacks and was diagnosed as having multiple sclerosis (MS) at the same time. The headache attacks resolved after i.v. treatment with methylprednisolone. MR imaging showed a pontine demyelinating lesion involving the trigeminal nerve root inlet area, on the same side as the pain. The association between cluster headache and MS has been rarely described before. This case suggests that in patients with cluster headache neuroimaging is often useful in order to exclude structural lesions.


Cluster headacheMultiple sclerosisBlink reflexMethylprednisolone