The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image
Open Access

Cluster headache and intracranial aneurysm

  • Marcelo Moraes Valença1Email author,
  • Luciana P. A. Andrade-Valença2,
  • Carolina Martins1,
  • Maria Fátima Vasco de Aragão1,
  • Laécio Leitão Batista1,
  • Mario Fernando Prieto Peres3 and
  • Wilson Farias da Silva1
The Journal of Headache and Pain20078:412

Received: 27 December 2006

Accepted: 14 September 2007

Published: 25 October 2007


In the present study we describe the cases of two patients with cluster-like headache related to intracranial carotid artery aneurysm. One of these patients responded to verapamil prescription with headache resolution. In both cases the surgical clipping of the aneurysm resolved the cluster pain. These findings strongly suggest a pathophysiological link between the two conditions. The authors discuss the potential pathophysiological mechanisms underlying cluster-like headache due to intracranial carotid artery aneurysm.


Cerebral aneurysmCluster headacheParasympatheticThird cranial nerveInternal carotid arteryPathophysiology


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