Open Access

Headache in a patient with Klinefelter’s syndrome and hyperostosis frontalis interna

The Journal of Headache and Pain20078:426

Received: 25 July 2007

Accepted: 13 October 2007

Published: 10 December 2007


Hyperostosis frontalis interna (HFI) has been reported in older women, but reports in men are rare. We present a novel case of migraine headache in a gentleman with Klinefelter’s syndrome and HFI, along with a discussion of possible pathophysiologic mechanisms underlying both the headache and the HFI.


Hyperostosis frontalis internaKlinefelter’s syndromeHeadacheMigraineOestrogen