Open Access

Headache in a patient with Klinefelter’s syndrome and hyperostosis frontalis interna

The Journal of Headache and Pain20078:426

https://doi.org/10.1007/s10194-007-0426-3

Received: 25 July 2007

Accepted: 13 October 2007

Published: 10 December 2007

Abstract

Hyperostosis frontalis interna (HFI) has been reported in older women, but reports in men are rare. We present a novel case of migraine headache in a gentleman with Klinefelter’s syndrome and HFI, along with a discussion of possible pathophysiologic mechanisms underlying both the headache and the HFI.

Keywords

Hyperostosis frontalis internaKlinefelter’s syndromeHeadacheMigraineOestrogen