Headache prevalence in the population of L’Aquila (Italy) after the 2009 earthquake
© The Author(s) 2011
Received: 1 October 2010
Accepted: 4 November 2010
Published: 18 February 2011
Stress induced by the events of daily life is considered a major factor in pathogenesis of primary tension-type headache. Little is known about the impact that could have a more stressful event, like a natural disaster, both in patients with chronic headache, both in people that do not had headache previously. The aim of the present study was to observe the prevalence of headache in the population following the devastating earthquake that affected the province of L’Aquila on April 6, 2009. The study population was conducted in four tent cities (Onna, Bazzano, Tempera-St. Biagio, Paganica). Sanitary access is recorded in the registers of medical triage, in the first 5 weeks, after the April 6, 2009. The prevalence of primary headache presentation was 5.53% (95% CI 4.2–7.1), secondary headache was 2.82% (95% CI 1.9–4.9). Pain intensity, assessed by Numerical Rating Scale score showed a mean value of 7 ± 1.1 (range 4–10). The drugs most used were the NSAIDs (46%) and paracetamol (36%), for impossibility of finding causal drugs. This study shows how more stressful events not only have an important role in determining acute exacerbation of chronic headache, but probably also play a pathogenic role in the emergence of primary headache. Also underlines the lack of diagnostic guidelines or operating protocols to early identify and treat headache in the emergency settings.
KeywordsPrimary and secondary headache Emergency setting Pharmacological treatment
Headache accounts for about 1.2–4.5% of all accesses to emergency room (ER) in the adult population . Secondary headache represents only 4.3–6.4% of cases . Italian current data indicate that up to 23% of all neurological consultancies in ER may be related to clinical conditions characterized by headache . Considering the high frequency of primary headache in ER during routine social sanitary activity, it is conceivable that the incidence of this condition may dramatically increase during catastrophic emergencies. After the earthquake of L’Aquila on April 6, 2009, Advanced Medical Presidiums (AMPs) were maintained in the region for a longer period than 72 h requested by law, because of the persistent difficulties in the sanitary organization. AMPs worked as ERs for patients affected by a large variety of pathological conditions, of different severity, including primary headache, either as symptom or disease in itself. As imaging techniques were not available for a diagnostic approach in the disaster area, medical history and accurate general and neurological examinations represented the most effective instruments for a correct diagnosis and exclusion of life-threatening conditions. Unfortunately, for the emergency physicians operating in- or extra-hospital setting, no guidelines or diagnostic algorithms are presently available for the diagnosis of primary headache including migraine, tension-type headache (TTH) and cluster headache, and more importantly for differentiating this condition from other organic causes of headache.
The aim of the present observational study was to estimate the prevalence of primary and secondary headache in the population afferent to the four Advanced Medical Presidiums (AMPs), during the post-seismic emergency period. The secondary aim was to evaluate the frequency of use, types of pain killers and the short-term efficacy of the pharmacological treatment of the neurological pain.
Materials and methods
WHITE = No emergency
GREEN = Secondary emergency
YELLOW = Primary emergency
RED = Extreme emergency
BLACK = Death.
Diagnosis of primary or secondary non traumatic headache (NT) by a simple questionnaire
Diagnostic questionnaire for headache NT
1.It is the first time you have headache? This is unusual headache, the most intense of which has ever suffered?
2.As the headache started?
3.Is there something that triggered the headache?
4.Where is localized the pain?
5.How intense is this headache (NRS score)?
6.What other symptoms is associated with headache?
7.How long have you suffer from headaches?
The prevalence of primary and secondary headache registered among the first accesses to the AMPs triage in the first 5 weeks after earthquake
5. Headache attributed to head and/or neck trauma
1.1 Migraine without aura
5.1 Acute post-traumatic headache
1.2 Migraine with aura
5.6 Headache attributed to other head/neck trauma
1.6 Probable migraine
2. Tension-type headache (TTH)
6. Headache attributed to cranial or vascular disorder
2.1 Infrequent episodic tension-type headache
2.2 Frequent episodic tension-type headache
2.3 Chronic tension-type headache
2.4 Probable tension-type headache
3. Cluster headache and other trigeminal autonomic cephalalgias
7. Headache attributed to non vascular intracranial disorder
7.6 Headache attributed to epileptic seizure
4. Other primary headache
8. Headache attributed to a substance or its withdrawal
4.1 Primary stabbing headache
4.2 Primary cough headache
10. Headache attributed to disorder of homoeostasis
10.3 Headache attributed to arterial hypertension
10.4 Headache attributed to hypothyroidism
10.7 Headache attributed to other disorder of homoeostasis
11. Headache or facial pain attributed to disorder of cranium, neck,
Eyes, ears, nose, sinuses, teeth, mouth or other facial or cranial
12. Headache attributed to psychiatric disorder
The large majority of primary headache in patients afferent to ER are of essential origin. In fact, up to 90% of patients suffering from headache are affected by the TTH or by migraine . The peculiar clinical context of the present observational study may provide some interesting clues. The population study was stratified by gender and age according to the epidemiological studies on primary headache reported in the literature . The different types of primary headache were distributed according to the prevalence observed in the general population . However, a substantial increment up to 70% of TTH forms was observed when compared with the 11% migraine and 20% remaining types (cluster, trigeminal, etc.). Secondary forms represented only 2.82% of the total, and were correctly diagnosed on the basis of the reported questionnaire and the accurate observation of the associated symptoms; obviously, these cases required a different therapeutic approach when compared with primary headache. The prevalence of primary headache was high, reaching a 16% of all post-seismic painful pathologies; also in relation to pathologies of other origin, primary headache represented the 5.53% of all causes of access to AMPs within the 5 weeks of the study. The shortage of diagnostic tools, including routine chemistry and imaging techniques, did not prevent a correct diagnosis of primary conditions that was mostly based on the exhaustive differential diagnosis. During a natural disasters, the clinical presentation of headache is super imposable in most of the cases; symptoms may be associated or masked by multiple external factors, including fasting, dehydratation, insomnia or panic. Overall, headache episodes may be induced by the stress related to the catastrophic event. A stressful event, indeed, has been shown to precipitate a pain episode of TTH or migraine . It has been hypothesized that a chronicizing stress, poor stress tolerance, prolonged physiological response to stressors or insufficient recovery from stress can cause headache, chronic pain and multiple physical disturbances . These factors support the observations of the present study. Several stress-related factors may have induced or worsened the episodes of headache. First of all, the uncomfortable life conditions, including living in tents, atmospheric agents, high temperature excursion (hot days, wintry nights and/or rain), small uncomfortable beds, hard physical work in order to meet personal and community daily life needs in the emergency centers. A drastic interruption of domestic and social habits as a consequence of the catastrophic event caused a deep sense of impotence and limitation of autonomy that seriously influenced individual and community mood . The time course and distribution of cases during the 5-week observation period shows that inadequate adaptation to multiple acute stressors directly or indirectly related to disaster played a key role in inducing headache episodes. The increased prevalence of primary headache, indeed, during 3 weeks after the earthquake may be related to the stress of the acute event and the associated factors including psycho-physical changes of individuals, due to acceptance, hope, resignation or other factors such as progressive improvement of social, hygienic and structural conditions and decreased intensity of the seismic swarm.
The high frequency of first episodes of primary headache is another distinctive element that underlines the importance of chronicizing stress in the pathogenesis of this condition. The “central” mechanisms of the disease may have been triggered off, in particular, by peripheral mechanisms such as contraction, hypersensitivity, pain of pericranial and cervical muscles, secondary to the above-mentioned hard life context. Overall, these elements may be responsible for increase of chronic forms after the catastrophic event . Several studies, indeed, have shown that activation of muscles of the pericranial areas related to pain may be induced directly by stress or by modulation of specific nociceptive afferences related to episodes of central sensitisation. In fact, central sensitisation is recognized as an important mechanism in the pathogenesis of primary headache, either TTH or migraine [11–13]. In the presence of a natural disaster, the relationship between stress and pain may perpetuate a dangerous vicious circle. The physiopathological mechanisms of headache may have amplified the role of the stressful event in cases exposed and stress, in turn, may have enhanced the relapse and/or appearance of pain. This vicious circle should be blocked also in emergency situations by the administration of effective analgesic drugs, in order to prevent pain chronicization, in particular, in post-traumatic cases. In the present study, drugs most frequently administered as pain relievers included paracetamol (36%) and non-steroid antiinflammatory drugs (46%); weak opioids (18%), either alone or associated with paracetamol were used in a smaller percentage of cases. The high intensity of pain (average NRS score 7 ± 1.1, severe pain) in the acute phase of headache often required a strict monitoring of vital parameters [BP, HR, BT (in °C), SpO2] and of the analgesic effect of drugs by the NRS score during the following 2 h. The decrease of pain intensity as assessed by the difference between NRS scores was the reference parameter for estimating the efficacy of drugs either immediately (T2h = first 2 h) as in the following 24–48 h (T24h and T48h). It is known that about two-third of patients complain new episodes of pain within 24 h after discharge from ER; in half of them, the intensity of pain is mild-severe . Up to 50% of patients report a functional disability within 24 h after the headache crisis causing the access to the ER . In the present study, 77% of patients required the administration of analgesic drugs up to 48 h after the onset of the crisis in order to control pain. This suggests that the mechanisms triggering and maintaining headache were operating for a longer period than the stress-induced peripheral and muscular mechanisms usually do. An early treatment, although with the limited number of drugs available, and a strict monitoring of patients, allowed us to substantially control pain, as shown by the decrease of the average NRS scores within 48 h (T48h = 1.8 ± 0.68). Figures 1, 2, 3 shows the time course of pain during the observation period. The choice of the drug, in the large majority of cases NSAIDs or paracetamol, according to medical history and characteristic of pain, was mostly influenced by the shortage of specific drugs, such as triptans , ergot derivatives , antiepileptic drugs , and narcotic analgesics . Analgesic drugs have been mainly administered orally; the oral route facilitated the therapeutic management of patients after discharge and improved their compliance to treatment during the following 48 h.
The present observational study has been markedly influenced by the adverse clinical setting in which it has been carried out and by the multifactorial pathogenesis of headache. The most important aspect of the study is that the observation of patients was protracted for 48 h, in a clinical condition characterized by shortage of sophisticated diagnostic instruments. The first steps for identifying primary headache in patients afferent to AMPs included an accurate medical history, a short questionnaire (no approved questionnaires for headache in ERs are available) and physical examination. Valuable information has been derived from vital parameters, such as body temperature, arterial blood pressure, cardiac frequency and NRS score. Further important diagnostic elements have been derived from physical examination, including palpation of the aching head and neck areas, and complete neurological examination. These simple elements allowed us to formulate a correct diagnosis and organize a therapeutic intervention for the following 48 h; this approach obtained a substantial control of pain in all primary forms. Specific potent drugs, including triptans and narcotic analgesics, were unavailable in our setting; this reveals a poor sanitary education and care in the treatment of headache and, more generally, of pain syndromes in emergency situations. This last consideration is of major concern due to the relevant prevalence of headache in natural disaster setting, the prognostic severity of secondary forms and the high risk of chronic headache.
The authors wish to acknowledge the assistance of the following organizations and individuals provided during the post earthquake period: V.A.Do. [Volontariato per l’Assistenza Domiciliare (Voluntary Home Help)]; The Paolo Procacci Fundation (FPP); AISD [Associazione Italiana per lo Studio del Dolore (Italian Association for the Study of Pain)]. Special thanks to Ms Anna Venturato for her help in preparing the manuscript. No financial support was received to perform this clinical observation.
Conflict of interest
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- Morgenstern LB, Huber JC, Luna-Gonzales H et al (2001) Headache in the emergency department. Headache 41(6):537–541, 11437887, 10.1046/j.1526-4610.2001.041006537.x, 1:STN:280:DC%2BD38%2FhvFKguw%3D%3DView ArticlePubMedGoogle Scholar
- Ducros A (2001) Abstract presented at the 10th Congress of the International Headache Society, June 29–July 2, 2001, New York, NY. Cephalalgia 21:241–548, 10.1046/j.1468-2982.2001.00001.xView ArticleGoogle Scholar
- de Falco FA (2004) Sentinel headache. Neurol Sci 25:S215–S217, 15549540, 10.1007/s10072-004-0289-1View ArticlePubMedGoogle Scholar
- Friedman BW, Hochberg ML, Esses D et al (2007) Applying the international classification of headache disorders to the emergency department: an assessment of reproducibility and the frequency with which a unique diagnosis can be assigned to every acute headache presentation. Ann Emerg Med 49(4):409–419, 17210203, 10.1016/j.annemergmed.2006.11.004View ArticlePubMedGoogle Scholar
- Schwartz BS, Stewart WF, Simon D, Lipton RB (1998) Epidemiology of tension-type headache. JAMA 279:381–383, 9459472, 10.1001/jama.279.5.381, 1:STN:280:DyaK1c7hvFGlsg%3D%3DView ArticlePubMedGoogle Scholar
- Stovner LJ, Zwart JA, Hagen K, Terwindt GM, Pascual J (2006) Epidemiology of headache in Europe. Eur J Neurol 13:333–345, 16643310, 10.1111/j.1468-1331.2006.01184.x, 1:STN:280:DC%2BD283jslSmtw%3D%3DView ArticlePubMedGoogle Scholar
- Ehde DM, Holm JE (1992) Stress and headache: comparisons of migraine, tension, and headache-free subjects. Headache 3:54–60Google Scholar
- Hatch JP, Prihoda TJ, Moore PJ et al (1991) A naturalistic study of the relationships among electromyographic activity, psychological stress, and pain in ambulatory tension-type headache patients and headache-free controls. Psychosom Med 53:576–584, 1758943, 1:STN:280:DyaK387gtVyhtQ%3D%3DView ArticlePubMedGoogle Scholar
- Wittrock DA, Myers TC (1998) The comparison of individuals with recurrent tension-type headache and headache-free controls in physiological response, appraisal, and coping with stressors: a review of the literature. Ann Behav Med 20:118–134, 9989318, 10.1007/BF02884458, 1:STN:280:DyaK1M7ktlylsQ%3D%3DView ArticlePubMedGoogle Scholar
- Chen Y (2009) Advances in the pathophysiology of tension-type headache: from stress to central sensitization. Curr Pain Headache Rep 13:484–494, 19889292, 10.1007/s11916-009-0078-xView ArticlePubMedGoogle Scholar
- Holstege G (1992) The emotional motor system. Eur J Morphol 30:67–79, 1642954, 1:STN:280:DyaK38zlt1yruw%3D%3DPubMedGoogle Scholar
- Bendtsen L (2000) Central sensitization in tension-type headache-possible pathophysiological mechanisms. Cephalalgia 20:486–508, 11037746, 10.1046/j.1468-2982.2000.00070.x, 1:STN:280:DC%2BD3cvoslCrug%3D%3DView ArticlePubMedGoogle Scholar
- Burstein R (2001) Deconstructing migraine headache into peripheral and central sensitization. Pain 89:107–110, 11166465, 10.1016/S0304-3959(00)00478-4, 1:STN:280:DC%2BD3M3ksFCnsQ%3D%3DView ArticlePubMedGoogle Scholar
- Friedman BW, Grosberg BM (2009) Diagnosis and management of the primary headache disorders in the emergency department setting. Emerg Med Clin N Am 27(1):71, 10.1016/j.emc.2008.09.005View ArticleGoogle Scholar
- Ducharme J et al (1998) Emergency management of migraine: is the headache really over? Acad Emerg Med 5(9):899–905, 9754503, 1:STN:280:DyaK1cvisFCktg%3D%3DView ArticlePubMedGoogle Scholar
- Vinson DR (2002) Treatment patterns of isolated benign headache in US emergency departments. Ann Emerg Med 39(3):215–222, 11867972, 10.1067/mem.2002.121400View ArticlePubMedGoogle Scholar
- Colman I et al (2005) Parenteral dihydroergotamine for acute migraine headache: a systematic review of the literature. Ann Emerg Med 45(4):393–401, 15795718, 10.1016/j.annemergmed.2004.07.430View ArticlePubMedGoogle Scholar
- Tanen DA et al (2003) Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial. Ann Emerg Med 41(6):847–853, 12764341, 10.1067/mem.2003.195View ArticlePubMedGoogle Scholar
- Colman I et al (2004) Use of narcotic analgesics in the emergency department treatment of migraine headache. Neurology 62(10):1695–1700, 15159464, 1:STN:280:DC%2BD2c3mtVarsQ%3D%3DView ArticlePubMedGoogle Scholar