The Journal of Headache and Pain

"European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image
Open Access

Migraine comorbidity: from genotype to phenotype

  • Guiseppe Nappi,
  • Alfredo Costa,
  • Daniela Fortini,
  • Maria G. Damiano,
  • Carlo Casali,
  • Francesco Pierelli and
  • Filippo M. Santorelli
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S115.10194


In this paper, we review the “current” and “ancient” concepts of comorbidity in migraine attack and disease. We emphasize the role of migraine as a complex disease and stress the appropriate consideration that genetic determinants require in modern taxonomy of migraine headaches. Novel attempts to revise migraine nosography should consider the complexity of genotype-phenotype-environment interactions in order to identify more rational approaches to treatment.

Key words ChannelopathyComorbidityGenotypeHeterogeneityMigrainePhenotype