The Journal of Headache and Pain

"European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image
Open Access

Dopamine genes and migraine

  • Maria Antonietta Palmas,
  • Alessandra Cherchi,
  • Erminia Stochino,
  • Donatella Congiu and
  • Maria Del Zompo
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S153.10194


Migraine is a common chronic disorder with an etiology still mostly unknown. Several neurotransmitters such as dopamine and serotonin are considered to be involved in the pathogenesis of the disease and the study of their systems is crucial in the understanding of migraine. Dopaminergic receptors are variously represented in human CNS and periphery. The hypothesis that a hypersensitivity of the dopaminergic system may have a role in migraine is based on clinical and genetic data. Genetic data are represented by association studies using dopaminergic genes as candidate genes which show that the D2 receptor gene appears to be involved in the pathogenesis of migraine.

Key words MigraineGeneticsDopamineHypersensitivity