The Journal of Headache and Pain

"European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image
Open Access

HLA in migraine and coeliac children

  • Elisabetta Tozzi,
  • Gabriele Renzetti,
  • Immaccolata Florio,
  • Gabriella Cascani,
  • Giovanni Conti,
  • Teresa Gentile and
  • Franco Papola
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S173.10194


The linkage between HLA antigens and disease susceptibility has been investigated in several diseases. Two different mechanisms are known to act in the relation between the HLA system and headache: linkage and association of alleles. Among neurological disorders associated with coeliac disease (CD) we focused on headache in 1997. From a group of 70 coeliac children, we studied 10 children with headache (3 boys and 7 girls). For each subject we evaluated clinical history and HLA antigens. The incidence of headache was not different with respect to the prevalence of headache in the general population. The HLA setting is not different between the 2 groups examined. However, we highlight 2 cases for the particular HLA setting.

Key words Coeliac diseaseHeadacheChildrenHLA antigens