Open Access

Prothrombotic genetic risk factors in chronic daily headache

  • Francesco Bono,
  • Elvira Valeria De Marco,
  • Alessandra Lucisano,
  • Donatella Civitelli,
  • Domenico Pirritano,
  • Chiara Cantafio,
  • Angelo Labate and
  • Maria Rosaria Lupo
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S183.10194


The aetiology of chronic daily or near-daily headache (CDH) is unknown. We evaluated prothrombotic genetic risk factors (factor V G1691A, factor II 20210 G/A, methylenetetrahydrofolate reductase mutations and plasminogen activator inhibitor-1 4G/5G polymorphism) in 100 patients with CDH, and in 73 healthy controls. Patients did not differ from controls for the studied prothrombotic polymorphisms. These findings suggest that prothrombotic genetic risk factors do not play a role in the development of CDH.

Key words Chronic daily headacheHemostasisGenetic risk factors