The Journal of Headache and Pain

"European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image
Open Access

Planet pain: focus on chronic migraine

  • Maria Nicoladi and
  • Federigo Sicuteri
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches1:0001S011.10194


Chronic headache is often described but pooly understood regarding its mechanisms. We discuss the clinical presentation, differential diagnosis of chronic headache syndromes and treatment options. Patients presenting these pain syndromes are best assessed using a multidisciplinary approach. Our purpose was to investigate these types of chronic primary pain by using an internal medicine, neurological as well as a pain-specialist approach. We developed a model for estimating the entity of central sensitization, which seems to be the pivotal feature in these painful syndromes. Our approach allowed us to gain further insight into the mechanism of central sensitization and neuronal changes in the central nervous system. The findings run counter to the possibility that these primary pain syndromes, especially chronic migraine, are refractory to specific treatments.

Key words Visceral sensory innervationSomatic sensory innervationHyperalgesiaGenetic hyperalgesiaChronic migraineNMDA receptor