The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image
Open Access

Neurophysiology of migraine

  • Giorgio Sandrini1Email author,
  • Alberto Proietti Cecchini1,
  • Sonya Ivanova Hristova1, 2,
  • Grazia Sances1 and
  • Giuseppe Nappi1, 3
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches and the Italian Society of Pain Clinicians2:13


We review the main electrophysiological abnormalities emerging from migraine studies and discuss them from the pathophysiological point of view. Considerations range from genetic aspects to the heterogeneous clinical phenotype of migraine.

Migraine trait Cortical excitabilityTrigeminal reflexHabituationTrigeminovascular system



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