Open Access

Do changes of ANS in migraine subjects play a pathogenetic role?

  • Pietro Cortelli1,
  • Sabina Cevoli2,
  • Giuseppe Bonavina2,
  • Fabiola Magnifico2 and
  • Giulia Pierangeli2Email author
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches and the Italian Society of Pain Clinicians2:14


Migraine, characterized by several autonomic disturbances both during and between attacks, suggests an involvement of the autonomic nervous system (ANS). To clarify the role of the ANS in migraine pathogenesis, we reviewed the major studies on autonomic function. The results of these investigations are contradictory, suggesting hypo– and hyperfunctioning of both the sympathetic and parasympathetic nervous systems.

Autonomic nervous system Migraine Pathogenesis