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The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

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Open Access

Visual stress–induced migraine aura compared to spontaneous aura studied by magnetoencephalography

  • K. Michael A. Welch1Email author,
  • Susan M. Bowyer2,
  • Sheena K. Aurora3,
  • John E. Moran2 and
  • Norman Tepley2
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches and the Italian Society of Pain Clinicians2:26


DC MEG shifts, similar and complex in waveform, were observed in visually induced migraine with aura patients similar to spontaneous aura but not controls. Multiple cortical areas were activated in visually induced and spontaneous aura patients. In normal subjects activation was only observed in the primary visual cortex. Results support a spreading depression–like neuroelectric event as the basis of migraine aura that can arise spontaneously or be visually triggered in widespread regions of hyperexcitable occipital cortex.

DC MEGMigraine with auraMigraine without auraOccipital hyperexcitability



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