The Journal of Headache and Pain

"European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

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A patient with SUNCT syndrome responsive to sodium valproate

  • Piero Meineri,
  • Fiorella Mondino and
  • Enzo Grasso
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches3:00034


SUNCT syndrome (shortlasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) is a rare, debilitating headache that is difficult to be treated. We describe a SUNCT patient, initially treated with lamotrigine, with a positive response but with an unbearable side-effect (somnolence) that lead to withdrawal. The drug was replaced with sodium valproate at a dosage of 1000 mg b.i.d.. Complete remission of the attacks has been obtained for 1 year, without significant side effects.

Key words SUNCTValproateTreatment