The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image
Open Access

Pharmacological analysis of red-wine-induced migrainous headaches

  • Richard C. Peatfield,
  • Gordon Fletcher,
  • Keith Rhodes,
  • Ian M. Gardiner and
  • Jacqueline de Belleroche
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches4:00023


We describe a series of experiments designed to investigate the mechanisms by which headaches can be triggered by red wine in a small minority of migraine patients. Some red wines are particularly potent releasers of serotonin from platelet stores, but these are no more effective as triggers of headache in sensitive patients. Both the selective 5-HT2A antagonist ketanserin and the non-selective 5-HT2ABC antagonist pizotifen blocked the majority of headaches, and we then thought the antihistamine properties of these two drugs might be important. In a third experiment, however, the H1 antagonist mepyramine did not convincingly antagonise the response to red wine. Plasma levels of the enzyme diamine oxidase, which metabolises histamine, were lower in all migraine patients, whether or not they were sensitive to red wine. The results reported here do not permit making firm conclusions; nevertheless it seems that different pharmacological receptors may be responsible in different patients.

Key words HeadacheFood sensitivityWine5HT2 receptorsHistamine H1 receptors



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