Volume 15 Supplement 1

Abstracts from the 4th European Headache and Migraine Trust International Congress: EHMTIC 2014

Open Access

EHMTI-0084. Resting state functional connectivity abnormalities in pediatric patients with migraine

  • R Messina1,
  • MA Rocca1,
  • B Colombo2,
  • E De Meo1,
  • A Falini3,
  • G Comi2 and
  • M Filippi1
The Journal of Headache and Pain201415(Suppl 1):B22


Published: 18 September 2014


Previous resting state (RS) functional magnetic resonance imaging (fMRI) studies in adult patients with migraine have demonstrated abnormal functional connectivity (FC) of brain networks involved in pain processing, including the default mode (DMN), the salience (SN) and the executive control (ECN) network.


To explore abnormalities of brain RS FC in pediatric patients with migraine and their correlation with patients’ clinical characteristics.


Using a 3.0 Tesla scanner, RS fMRI scans were acquired from 13 pediatric migraine patients and 15 age-matched controls. Independent component analysis and a template-matching procedure were used to identify the DMN, ECN, working memory networks (WMN), SN, sensorimotor (SM), auditory and visual (VN) networks. Within-group and between-group RS FC comparisons and analysis of correlation were performed using SPM8.


Compared to controls, pediatric migraine patients had an increased RS FC of the orbito-frontal, middle and posterior cingulate gyrus of the DMN and WMNs, the inferior temporal gyrus of the ECN, the rolandic operculum and lingual gyrus of the WMNs and the postcentral gyrus of the VN. They also experienced a decreased RS FC of the anterior cingulum of the SN, the middle temporal gyrus and cerebellar vermis of the WMNs and the superior temporal gyrus of the SM. Altered RS FC of the temporal lobes of the ECN and WMN was correlated with disease duration and attack frequency.


In pediatric migraine patients, distributed abnormalities of brain RS FC occur and engage not only pain-facilitating and pain-inhibiting regions, but also areas involved in executive processes.

No conflict of interest.

Authors’ Affiliations

Neuroimaging Research Unit and Dept. of Neurology, Scientific Institute and University Hospital San Raffaele
Dept. of Neurology, Scientific Institute and University Hospital San Raffaele
Dept. of Neuroradiology, Scientific Institute and University Hospital San Raffaele


© Messina et al; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.