The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

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Volume 15 Supplement 1

Abstracts from the 4th European Headache and Migraine Trust International Congress: EHMTIC 2014

Open Access

EHMTI-0330. The prevalence of undifferentiated connective tissue dysplasia syndrome in children with migraine

  • Y Nesterovskiy1 and
  • N Zavadenko1
The Journal of Headache and Pain201415(Suppl 1):D44

Published: 18 September 2014


Internal MedicineGeneral PopulationMigraineCongenital HeartNegative Influence


The efficiency of migraine therapy depends on it's co-morbidities. One of these co-morbidities is represented by undifferentiated connective tissue dysplasia (UCTD). In general population the joint hypermobility syndrome (JHS) may be present in 5-30% (Murray K.J., 2001) and minor congenital heart defects (MCHDs) in 5-35% (Freed L.A., 1999). In adults approximately 75% of patients with JHM suffer migraine (Bendik E.M., 2011).


to study the manifestations of JHS and MCHDs in children and adolescents with migraine compared with their peers suffering tension-type headache (TTH).


109 children and adolescents with migraine with/without aura established by the diagnostic criteria of ICHD-2 were included into the study. The control group included 50 patients with TTH. The JHS was confirmed according to P.H. Beighton's scored assessment (1999). MCHDs were diagnosed by the heart ultrasound examination.


The signs of UCTD were revealed in 76 (69%) of patients with migraine. JHS was confirmed in 68 (62%). MCHDs were found in 42 (38%).

In TTH patients the manifestations of UCTD were noted in only 21 (42%) of cases in the form of JHS and in 9 (18%) as MCHDs, which rates are similar to the literature data for general population.


High prevalence of UCTD manifestations in child and adolescent migraine patients can influence the frequency and severity of migraine attacks and worsen the patients' somatic status which may have the negative influence on their quality of life.

No conflict of interest.

Authors’ Affiliations

Neurology Neurosurgery and Medical Genetics Department of Pediatric Faculty, N.I. Pirogov’s Russian National Research Medical University, Moscow, Russia


© Nesterovskiy and Zavadenko; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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