The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

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Volume 15 Supplement 1

Abstracts from the 4th European Headache and Migraine Trust International Congress: EHMTIC 2014

Open Access

EHMTI-0168. Primary headache associated with sexual activity: fifteen new cases and therapeutic results

  • K Zhu1,
  • Y Huang2 and
  • J Chen2
The Journal of Headache and Pain201415(Suppl 1):D77

Published: 18 September 2014


Adverse EffectInformed ConsentPropranololClinical ManifestationIndomethacin


Primary headache associated with sexual activity (PHASA) is a rare benign headache disorder.To our knowledge, this is the first Chinese mainland fifteen cases.


To explore the clinical manifestations,diagnosis,treatment and prognostic features of PHASA.


Fifteen patients,11 men,4 women,from 26 to 56 years old(mean 42±11),were prospectively analyzed over the past more than 7 years in our hospitals.The study was approved by our hospital Review Boardand and all of subjects have signed written informed consent.


Their ages of onset were from 26 to 44 years old(mean 38 ± 7 ). For preemptive therapy, 8 patients had received indomethacin (25–50 mg, intake 30–60 min prior to sexual activity). 7 patients reported good results and one limited success of this treatment and 4 patients had received sumatriptan (50-100mg, intake 30–60 min prior to sexual activity). 2 patients reported good results and remaining 2 had no response. They received ibuprofen for preemptive therapy complete success. Prophylactic treatment with propranolol was given in 8 patients. The dose was 60 mg for propranolol. Six patients reported good results, two no success of propranolol prophylaxis. Other drug applied for prophylaxis was nimodipine in 4 patients,two success and two without success.


The patient who is diagnosed with PHASA should firstly receive indomethacin, or other drugs, sumatriptan, ibuprofen, is used for preemptive therapy if she/he can not get relief and(or)tolerate the adverse effects and should firstly receive propranolol, or other drug, nimodipine, is used for prophylaxis if she/he can not get relief and(or)tolerate the adverse effects.

No conflict of interest.

Authors’ Affiliations

Neurology, Panyu Hospital of Chinese Medicine, Guangzhou, China
Neurology, Guangdong No.2 provincial people’s hospital, Guangzhou, China


© Zhu et al; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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