The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image

Volume 15 Supplement 1

Abstracts from the 4th European Headache and Migraine Trust International Congress: EHMTIC 2014

Open Access

EHMTI-0182. Positive family history of migraine predisposes to a reduced migraineurs visual cortical reactivity

  • G Coppola1,
  • M Bracaglia2,
  • D Di Lenola2,
  • G Di Ciaccia2,
  • C Di Lorenzo2,
  • V Parisi1 and
  • F Pierelli2
The Journal of Headache and Pain201415(Suppl 1):E8

Published: 18 September 2014


MigraineHealthy VolunteerRepetition RateCritical ThresholdPositive Family History


In migraine, the genetic load can be seen as determining, on the one hand, a critical threshold for the disease development, and on the other hand, it may be responsible for interictal nervous system electrophysiological abnormality.


Here, we were aimed to verify whether having a positive family history of migraine might influence cortical abnormal information processing in migraine patients.


We retrospectively collected 109 migraine patients from those reviewed who had visual evoked potentials (VEPs) recordings (6 blocks of 100 sweeps, 15 min of arc cheques, 3.1 repetition rate) and information about parental history of migraine. Neurophysiological recording data were compared with those of 42 healthy volunteers (HV) without a personal or family history of migraine.


We recruited 85 patients with and 24 without a positive family history of migraine. Patients who had one parent affected (mother or father) had significantly lower N75-P100 VEP amplitude blocks overall than those had no parents affected, the latter resulting not different from HV. Lack of VEP N75-P100 amplitude habituation was found in overall migraineurs compared with HV, irrespectively of whether they had a parent affected or not.


These findings suggest that familial occurrence of migraine may predispose to a general reduced cortical reactivity to visual stimulation.

No conflict of interest.

Authors’ Affiliations

Department of Neurophysiology of Vision and Neurophthalmology, G.B. Bietti Foundation-IRCCS, Roma, Italy
Department of medico-surgical sciences and biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy


© Coppola et al; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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