Volume 16 Supplement 1
O005. Efficacy of oral supplement compared with amitriptyline in the prophylaxis of episodic tension-type headache and migraine without aura
© Ciccone et al. 2015
Published: 28 September 2015
We conducted an observational study of patients attending our outpatient headache clinic, suffering from episodic tension-type headache (ETTH) and migraine without aura (MO). The purpose of the study was to compare the efficacy of magnesium bisglycinate, L-tryptophan, niacin, vitamin B2 and vitamin D, pineal tens (PT) and amitriptyline (A) in the prophylaxis [1–4] of these primary headaches using as outcomes: pain modification with visual analogue scale (VAS); the change in the number of attacks/month; the change in the consumption of analgesics/month.
Patients and methods
ETTH and MO were diagnosed according to the International Classification ICHD-II criteria. We studied a total of 200 patients: 100 patients were diagnosed with ETTH and 100 with MO. Of these patients, 50 with a diagnosis of ETTH (15 M, 35 F; mean age: 34 years) were treated with PT (1 sachet morning and evening) and were compared with 50 patients (17 M, 33 F; mean age: 39 years) undergoing amitriptyline therapy (20 mg in the evening). Fifty patients with MO (15 M, 35 F; mean age: 37 years) were treated with PT (1 sachet morning and evening), and compared with 50 patients (8 M, 42 F; mean age: 40 years) taking A (20 mg in the evening).
Our clinical observation of an improvement in headache in patients receiving PT led us to conduct this cohort study comparing PT with A therapy. Although this study is obviously limited because of the absence of patient randomization, its results confirm the clinical impression of an improvement in the primary headache in patients with PT in terms of improvement in VAS, reduction in the number of attacks/month, and the consumption of analgesics/month. In fact, PT treatment was found to be more efficacious when compared to A treatment in many outcome measures.
Written informed consent to publish was obtained from the patient(s).
- Blanchard EB, Andrasik F, Ahles TA, Teders SJ, O'Keefe D: Migraine and tension headache: a meta-analytic review. Behavior Therapy. 1980, 11 (5): 613-631.View ArticleGoogle Scholar
- Buse DC, Andrasik F: Behavioral medicine for migraine. Neurol Clin. 2009, 27 (2): 445-465.View ArticlePubMedGoogle Scholar
- Gallai V, Pini LA: Trattato delle cefalee. 2002, Torino, Centro Scientifico EditoreGoogle Scholar
- Gionco M: Diagnosi e terapia del dolore cranio-facciale primario e secondario. Manuale delle cefalee 2011. 2011, Milano: LingomedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.