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The Journal of Headache and Pain

Official Journal of the "European Headache Federation" and of "Lifting The Burden - The Global Campaign against Headache"

The Journal of Headache and Pain Cover Image

Volume 16 Supplement 1

1st Joint ANIRCEF-SISC Congress

Open Access

O053. Interictal cerebral posterior circulation in migraineurs with aura: a trancranial color-coded duplexsonography pilot study

  • Antonio Siniscalchi1Email author,
  • Luca Gallelli2 and
  • Rosario Iannacchero3
The Journal of Headache and Pain201516(Suppl 1):A159

Published: 28 September 2015


Informed ConsentMigrainePilot StudyMigraineur PatientOccipital Cortex


Vascular cerebral dysfunction restricted to the posterior circulation in migraineurs has been reported. In this preliminary study we compared mean flow diastolic velocity in the posterior cerebral artery during visual stimulation in interictal state headache-free subjects and migraineurs with aura.

Matherials and methods

Trancranial color-coded duplexsonography was used to assess mean flow diastolic and systolic velocity changes in the posterior cerebral artery, in particular P2, during visual stimulation.


An increase in vascular reactivity of mean flow diastolic velocity was observed during visual stimulation in headache-free subjects (Group 1, 10 patients) and in the patients affected by migraine with aura (Group 2, 7 patients), without any differences between right and left sides. Reactivity of mean flow diastolic velocity to visual stimulation was found significantly higher in Group 2 (mean ±SD, 42%±2.6%) vs Group 2 (mean SD, 33.6%±1.8%) (p < 0.001). In contrast, no differences in flow systolic velocity between the two groups were observed.


These results indicate that occipital cortex is involved in migraineur patients with aura. Moreover, these patients exhibit a larger cerebrovascular response during visual stimulation compared to headache-free subjects.

Written informed consent to publish was obtained from the patient(s).

Authors’ Affiliations

Department Neurology, Coordinator DAMA (Disabled Advanced Medical Assistance), “Annunziata” Hospital, Cosenza, Italy
Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Catanzaro, Italy
Department of Neurology, Regional Headache Research Center, “Pugliese-Ciaccio” Hospital, Catanzaro, Italy


© Siniscalchi et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.


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