Volume 16 Supplement 1

1st Joint ANIRCEF-SISC Congress

Open Access

O028. Thalamo-cortical network changes during the migraine cycle: insights from MRI-based microstructural and functional resting-state network correlation analysis

  • Gianluca Coppola1Email author,
  • Antonio Di Renzo1,
  • Emanuele Tinelli2,
  • Chiara Lepre3,
  • Elisa Iacovelli3,
  • Cherubino Di Lorenzo4,
  • Giorgio Di Lorenzo5,
  • Vincenzo Parisi1,
  • Mariano Serrao6,
  • Flavia Pauri3,
  • Giancarlo Fiermonte3,
  • Claudio Colonnese3,
  • Jean Schoenen7 and
  • Francesco Pierelli8
The Journal of Headache and Pain201516(Suppl 1):A52

https://doi.org/10.1186/1129-2377-16-S1-A52

Published: 28 September 2015

The Erratum to this article has been published in The Journal of Headache and Pain 2017 18:11

Background

Abnormal structural and functional plasticity in cortical and subcortical brain regions may be an important aspect of migraine pathophysiology. Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Whether there is a relation between the plasticity of resting state networks and integrity of thalamic microstructure during the migraine cycle is not known. To verify functional connectivity between brain networks at rest and its relationship with thalamic microstructure in migraine without aura (MO) patients during and between attacks.

Methods

Twenty-four patients with untreated MO underwent 3T MRI scans during (n=10) or between attacks (n=14) and were compared to a group of 15 healthy volunteers. We used MRI to collect resting state data among four selected resting state networks, identified using group independent component (IC) analysis. Fractional anisotropy (FA) values of bilateral thalami were retrieved from a previous diffusion tensor imaging study on the same group of subjects and correlated with resting state ICs Z-scores.

Results

We found a significant reduced functional connectivity between the default mode network and the visuo-spatial system between attacks, and between the executive control network and the dorso-ventral attention system during attacks. When HV and migraine groups were combined, ictal and interictal selected ICs Z-scores correlated negatively with bilateral thalami FA values.

Conclusions

The present results are the first evidence supporting the hypothesis that abnormal dynamics of the connectivity between thalamus and functional cerebral networks at rest could contribute to the recurrence of migraine attacks.

Written informed consent to publication was obtained from the patient(s).

Notes

Authors’ Affiliations

(1)
Department of Neurophysiology of Vision and Neuro-ophthalmology, G.B. Bietti Foundation IRCCS
(2)
Department of Neurology and Psychiatry, Neuroradiology section, “Sapienza” University of Rome
(3)
Department of medico-surgical sciences and biotechnologies, Neurology section, “Sapienza” University of Rome
(4)
Don Carlo Gnocchi Onlus Foundation
(5)
Department of Systems Medicine, University of Rome “Tor Vergata”, Laboratory of Psychophysiology, Psychiatric Clinic
(6)
Department of medico-surgical sciences and biotechnologies, “Sapienza” University of Rome Polo Pontino
(7)
Headache Research Unit, Department of Neurology-CHR Citadelle, University of Liège
(8)
IRCCS Neuromed

Copyright

© Coppola et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.