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  1. Research

    Volumetric abnormalities of thalamic subnuclei in medication-overuse headache

    The thalamus exerts a pivotal role in pain processing and cortical excitability control and a previous voxel-based morphometry study confirmed increased volume in bilateral thalamus in medication-overuse heada...

    Zhiye Chen, Zhihua Jia, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma and Shengyuan Yu

    The Journal of Headache and Pain 2017 18:82

    Published on: 14 August 2017

  2. Research article

    The impact of onabotulinumtoxinA on severe headache days: PREEMPT 56-week pooled analysis

    OnabotulinumtoxinA has been shown to reduce headache-days among patients with chronic migraine (CM). The objective of this analysis was to determine whether onabotulinumtoxinA has an impact on headache-day sev...

    Manjit Matharu, Rashmi Halker, Patricia Pozo-Rosich, Ronald DeGryse, Aubrey Manack Adams and Sheena K. Aurora

    The Journal of Headache and Pain 2017 18:78

    Published on: 1 August 2017

  3. Research article

    OnabotulinumtoxinA injections in chronic migraine, targeted to sites of pericranial myofascial pain: an observational, open label, real-life cohort study

    OnabotulinumtoxinA has proven its efficacy in reducing the number of headache days in chronic migraine (CM) patients. The usual paradigm includes 31 pericranial injection sites with low dose (5 U) per site. Th...

    Danièle Ranoux, Gaelle Martiné, Gaëlle Espagne-Dubreuilh, Marlène Amilhaud-Bordier, François Caire and Laurent Magy

    The Journal of Headache and Pain 2017 18:75

    Published on: 21 July 2017

  4. Research article

    Assessment of gray and white matter structural alterations in migraineurs without aura

    Migraine constitute a disorder characterized by recurrent headaches, and have a high prevalence, a high socio-economic burden and severe effects on quality of life. Our previous fMRI study demonstrated that so...

    Jilei Zhang, Yi-Lan Wu, Jingjing Su, Qian Yao, Mengxing Wang, Ge-Fei Li, Rong Zhao, Yan-Hui Shi, Ying Zhao, Qiting Zhang, Haifeng Lu, Shuai Xu, Zhaoxia Qin, Guo-Hong Cui, Jianqi Li, Jian-Ren Liu…

    The Journal of Headache and Pain 2017 18:74

    Published on: 21 July 2017

  5. Research article

    Perceived stress in patients with migraine: a case-control study

    Perceived stress is the most common trigger for migraine. The objective of this study was to examine the clinical significance of perceived stress in migraine patients.

    Hye-Jin Moon, Jong-Geun Seo and Sung-Pa Park

    The Journal of Headache and Pain 2017 18:73

    Published on: 21 July 2017

  6. Research article

    Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal

    Hemicrania continua (HC), paroxysmal hemicrania (PH) and short lasting neuralgiform headache attacks (SUNCT and SUNA) are rare syndromes with a difficult therapeutic approach. The aim of this review is to summ...

    Carlo Baraldi, Lanfranco Pellesi, Simona Guerzoni, Maria Michela Cainazzo and Luigi Alberto Pini

    The Journal of Headache and Pain 2017 18:71

    Published on: 20 July 2017

  7. Research article

    Functional connectivity and cognitive impairment in migraine with and without aura

    Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of pre...

    Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Laura Rosa Pisani, Riccardo Lo Presti, Rosario Grugno, Giuseppe Di Lorenzo, Placido Bramanti and Silvia Marino

    The Journal of Headache and Pain 2017 18:72

    Published on: 20 July 2017

  8. Research article

    Anodal transcranial direct current stimulation over the left temporal pole restores normal visual evoked potential habituation in interictal migraineurs

    Neuroimaging data has implicated the temporal pole (TP) in migraine pathophysiology; the density and functional activity of the TP were reported to fluctuate in accordance with the migraine cycle. Yet, the exa...

    Francesca Cortese, Francesco Pierelli, Ilaria Bove, Cherubino Di Lorenzo, Maurizio Evangelista, Armando Perrotta, Mariano Serrao, Vincenzo Parisi and Gianluca Coppola

    The Journal of Headache and Pain 2017 18:70

    Published on: 19 July 2017

  9. Research article

    Is topiramate effective for migraine prevention in patients less than 18 years of age? A meta-analysis of randomized controlled trials

    Mainly based on evidence of success in adults, various medications are commonly used to prevent pediatric migraines. Topiramate has been approved for migraine prevention in children as young as 12 years of age...

    Kai Le, Dafan Yu, Jiamin Wang, Abdoulaye Idriss Ali and Yijing Guo

    The Journal of Headache and Pain 2017 18:69

    Published on: 18 July 2017

  10. Research article

    Migraine and the risk of post-traumatic stress disorder among a cohort of pregnant women

    Individually both migraine and post-traumatic stress disorder (PTSD) prevalence estimates are higher among women. However, there is limited data on the association of migraine and PTSD in women during pregnancy.

    Lauren E. Friedman, Christina Aponte, Rigoberto Perez Hernandez, Juan Carlos Velez, Bizu Gelaye, Sixto E. Sánchez, Michelle A. Williams and B. Lee Peterlin

    The Journal of Headache and Pain 2017 18:67

    Published on: 6 July 2017

  11. Research article

    Onabotulinumtoxin A for the management of chronic migraine in current clinical practice: results of a survey of sixty-three Italian headache centers

    Chronic migraine is a complex clinical condition often undertreated. Onabotulinumtoxin A (OBT-A) was approved in Italy in 2013 for symptom relief in patients with chronic migraine who have failed, or do not to...

    Cristina Tassorelli, Marco Aguggia, Marina De Tommaso, Pierangelo Geppetti, Licia Grazzi, Luigi Alberto Pini, Paola Sarchielli, Gioacchino Tedeschi, Paolo Martelletti and Pietro Cortelli

    The Journal of Headache and Pain 2017 18:66

    Published on: 30 June 2017

  12. Research article

    Post-traumatic headache in patients with minimal traumatic intracranial hemorrhage after traumatic brain injury: a retrospective matched case-control study

    No evidence is available on the risks of neurologically asymptomatic minimal traumatic intracranial hemorrhage (mTIH) in patients with traumatic brain injury (TBI) for post-traumatic headache (PTH). The purpos...

    Chang-Ki Hong, Yu Shik Shim, Sook Young Sim, Jin-Yang Joo, Min A Kwon, Yong Bae Kim and Joonho Chung

    The Journal of Headache and Pain 2017 18:64

    Published on: 26 June 2017

  13. Case report

    De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report

    Sporadic Hemiplegic Migraine is a rare form of migraine headache. Mutations in three different genes, two ion-channel genes and one encoding an ATP exchanger, CACNA1A, ATP1A2 and SCN1A are all responsible for the...

    Stella Gagliardi, Gaetano Salvatore Grieco, Francesca Gualandi, Luisa Maria Caniatti, Elisabetta Groppo, Marialuisa Valente, Giuseppe Nappi, Marcella Neri and Cristina Cereda

    The Journal of Headache and Pain 2017 18:63

    Published on: 7 June 2017

    The Erratum to this article has been published in The Journal of Headache and Pain 2017 18:68

  14. Research article

    Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca2+ levels in the perfused and non-perfused isolated rat middle cerebral artery

    Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilators identified to date. The present study elucidates the differential interaction of CGRP, its receptor and the effect of th...

    André Erdling, Majid Sheykhzade and Lars Edvinsson

    The Journal of Headache and Pain 2017 18:61

    Published on: 30 May 2017

  15. Research article

    Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center

    Central sensitization is an important epiphenomenon of the adult migraine, clinically expressed by allodynia, pericranial tenderness and comorbidity for fibromyalgia in a relevant number of patients. This stud...

    Marina de Tommaso, Vittorio Sciruicchio, Marianna Delussi, Eleonora Vecchio, Marvita Goffredo, Michele Simeone and Maria Grazia Foschino Barbaro

    The Journal of Headache and Pain 2017 18:59

    Published on: 30 May 2017

  16. Research article

    Post-traumatic headache: the use of the sport concussion assessment tool (SCAT-3) as a predictor of post-concussion recovery

    Given that post-traumatic headache is one of the most prevalent and long-lasting post-concussion sequelae, causes significant morbidity, and might be associated with slower neurocognitive recovery, we sought t...

    Olivia Begasse de Dhaem, William B. Barr, Laura J. Balcer, Steven L. Galetta and Mia T. Minen

    The Journal of Headache and Pain 2017 18:60

    Published on: 30 May 2017

  17. Research article

    The role of attachment insecurity in the emergence of anxiety symptoms in children and adolescents with migraine: an empirical study

    It is widely recognised that there are associations between headache, psychiatric comorbidity and attachment insecurity in both adults and children. The aims of this study were: 1) to compare perceived attachm...

    Riccardo Williams, Luigi Leone, Noemi Faedda, Giulia Natalucci, Benedetta Bellini, Elisa Salvi, Paola Verdecchia, Rita Cerutti, Marco Arruda and Vincenzo Guidetti

    The Journal of Headache and Pain 2017 18:62

    Published on: 30 May 2017

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